Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
"Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcriptional co-activator for NUCLEAR RECEPTORS. It is characterized by an N-terminal LxxLL sequence, a region that interacts with PPAR GAMMA, and a C-terminal RNA RECOGNITION MOTIF. It increases expression of MITOCHONDRIAL UNCOUPLING PROTEIN to regulate genes involved in metabolic reprogramming in response to dietary restriction and the integration of CIRCADIAN RHYTHMS with ENERGY METABOLISM.
Descriptor ID |
D000071248
|
MeSH Number(s) |
D12.644.360.024.314.650 D12.776.157.057.080.650 D12.776.157.725.813.875 D12.776.476.024.394.650 D12.776.660.675.650 D12.776.664.962.813.875 D12.776.930.617.650
|
Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha".
Below are MeSH descriptors whose meaning is more specific than "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha".
This graph shows the total number of publications written about "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" by people in this website by year, and whether "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
2016 | 0 | 1 | 1 |
2017 | 3 | 2 | 5 |
2018 | 4 | 4 | 8 |
2019 | 0 | 1 | 1 |
2021 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" by people in Profiles.
-
Transcriptomic studies revealed pathophysiological impact of COVID-19 to predominant health conditions. Brief Bioinform. 2021 11 05; 22(6).
-
Genes involved in mitochondrial biogenesis and function may not show synchronised responses to mitochondria in shell gland of laying chickens under infectious bronchitis virus challenge. BMC Mol Cell Biol. 2019 04 01; 20(1):3.
-
6-Gingerol Improves Ectopic Lipid Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle of Ageing Rats: Dual Stimulation of the AMPK/PGC-1a Signaling Pathway via Plasma Adiponectin and Muscular AdipoR1. Mol Nutr Food Res. 2019 03; 63(6):e1800649.
-
Cycling CD4+ T cells in HIV-infected immune nonresponders have mitochondrial dysfunction. J Clin Invest. 2018 11 01; 128(11):5083-5094.
-
AMPK/PGC1a activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis. Free Radic Biol Med. 2018 12; 129:59-72.
-
Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation: role in pulmonary arterial hypertension. J Hypertens. 2018 05; 36(5):1164-1177.
-
Telomere Dysfunction Disturbs Macrophage Mitochondrial Metabolism and the NLRP3 Inflammasome through the PGC-1a/TNFAIP3 Axis. Cell Rep. 2018 03 27; 22(13):3493-3506.
-
RIP140/PGC-1a axis involved in vitamin A-induced neural differentiation by increasing mitochondrial function. Artif Cells Nanomed Biotechnol. 2018; 46(sup1):806-816.
-
Cisplatin Enhances Hepatitis B Virus Replication and PGC-1a Expression through Endoplasmic Reticulum Stress. Sci Rep. 2018 02 22; 8(1):3496.
-
Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation. Cell Metab. 2018 02 06; 27(2):378-392.e5.