"APOBEC-3G Deaminase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An APOBEC deaminase that functions as an inhibitor of RETROVIRIDAE replication and inhibits the mobility of RETROTRANSPOSONS via deaminase-dependent and independent mechanisms. It is selective for SINGLE-STRANDED DNA and does not deaminate double-stranded DNA or single or DOUBLE-STRANDED RNA. It exhibits potent antiviral activity against VIF PROTEIN deficient HIV-1 through the creation of hypermutations in the VIRAL DNA. It also has anti-viral activity against SIMIAN IMMUNODEFICIENCY VIRUSES and HEPATITIS B VIRUS.
| Descriptor ID |
D000071480
|
| MeSH Number(s) |
D08.811.277.151.486.250.500.750
|
| Concept/Terms |
APOBEC-3G Deaminase- APOBEC-3G Deaminase
- APOBEC 3G Deaminase
- Deaminase, APOBEC-3G
- APOBEC-Related Cytidine Deaminase
- APOBEC Related Cytidine Deaminase
- Cytidine Deaminase, APOBEC-Related
- APOBEC3G Protein
- CEM15 Protein
- APOBEC3G Deaminase
- Deaminase, APOBEC3G
- APOBEC-3G Protein
- APOBEC 3G Protein
- APOBEC-Related Protein
- APOBEC Related Protein
- APOBEC-3G dC-dU Editing Enzyme
- APOBEC 3G dC dU Editing Enzyme
|
Below are MeSH descriptors whose meaning is more general than "APOBEC-3G Deaminase".
Below are MeSH descriptors whose meaning is more specific than "APOBEC-3G Deaminase".
This graph shows the total number of publications written about "APOBEC-3G Deaminase" by people in this website by year, and whether "APOBEC-3G Deaminase" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 3 | 3 | 6 |
| 2018 | 1 | 0 | 1 |
| 2019 | 2 | 0 | 2 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "APOBEC-3G Deaminase" by people in Profiles.
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Differentially expressed immune response genes in COVID-19 patients based on disease severity. Aging (Albany NY). 2021 03 29; 13(7):9265-9276.
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ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Cell Host Microbe. 2019 07 10; 26(1):86-99.e7.
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Polymorphisms in the APOBEC3G gene of Chinese rhesus macaques affect resistance to ubiquitination and degradation mediated by HIV-2 Vif. Arch Virol. 2019 May; 164(5):1353-1360.
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Presence of Human Papillomavirus (HPV) Apolipoprotein B Messenger RNA Editing, Catalytic Polypeptide-Like 3 (APOBEC)-Related Minority Variants in HPV-16 Genomes From Anal and Cervical Samples but Not in HPV-52 and HPV-58. J Infect Dis. 2018 08 24; 218(7):1027-1036.
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Moloney leukemia virus 10 (MOV10) inhibits the degradation of APOBEC3G through interference with the Vif-mediated ubiquitin-proteasome pathway. Retrovirology. 2017 Dec 19; 14(1):56.
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Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G. Nat Microbiol. 2018 02; 3(2):220-233.
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Anti-HIV Activities and Mechanism of 12-O-Tricosanoylphorbol-20-acetate, a Novel Phorbol Ester from Ostodes katharinae. Molecules. 2017 Sep 08; 22(9).
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Proviral Features of Human T Cell Leukemia Virus Type 1 in Carriers with Indeterminate Western Blot Analysis Results. J Clin Microbiol. 2017 09; 55(9):2838-2849.
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Hepatitis B virus X protein is capable of down-regulating protein level of host antiviral protein APOBEC3G. Sci Rep. 2017 01 18; 7:40783.
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Synthesis, biological evaluation and molecular docking study of N-(2-methoxyphenyl)-6-((4-nitrophenyl)sulfonyl)benzamide derivatives as potent HIV-1 Vif antagonists. Eur J Med Chem. 2017 Mar 31; 129:310-324.