"Histone Deacetylase 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class II histone deacetylase that removes acetyl groups from N-terminal LYSINES of HISTONE H2A; HISTONE H2B; HISTONE H3; and HISTONE H4. It plays a critical role in EPIGENETIC REPRESSION and regulation of GENETIC TRANSCRIPTION, as well as CELL MOTILITY through deacetylation of TUBULIN. It also targets misfolded proteins for clearance by AUTOPHAGY when MOLECULAR CHAPERONE-mediated folding is overwhelmed.
| Descriptor ID |
D000073864
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| MeSH Number(s) |
D08.811.277.087.520.350
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Histone Deacetylase 6".
Below are MeSH descriptors whose meaning is more specific than "Histone Deacetylase 6".
This graph shows the total number of publications written about "Histone Deacetylase 6" by people in this website by year, and whether "Histone Deacetylase 6" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 0 | 1 |
| 2018 | 3 | 1 | 4 |
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Below are the most recent publications written about "Histone Deacetylase 6" by people in Profiles.
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[Down-regulation of HDAC6 Expression Promotes Apoptosis of Human Leukemia K562 Cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Dec; 26(6):1626-1631.
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Pin1 Is Involved in HDAC6-mediated Cancer Cell Motility. Int J Med Sci. 2018; 15(13):1573-1581.
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Inhibition of HDAC6 Activity Alleviates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Potential Role of Peroxiredoxin 1 Acetylation and Redox Regulation. Oxid Med Cell Longev. 2018; 2018:9494052.
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iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated a-tubulin defect which improves after iHDAC6 treatment in Rett syndrome. Exp Cell Res. 2018 07 15; 368(2):225-235.
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Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin. J Med Chem. 2017 11 09; 60(21):9090-9096.