Amino Acid Chloromethyl Ketones
"Amino Acid Chloromethyl Ketones" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the translation process.
| Descriptor ID |
D000590
|
| MeSH Number(s) |
D12.125.065
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Amino Acid Chloromethyl Ketones".
Below are MeSH descriptors whose meaning is more specific than "Amino Acid Chloromethyl Ketones".
This graph shows the total number of publications written about "Amino Acid Chloromethyl Ketones" by people in this website by year, and whether "Amino Acid Chloromethyl Ketones" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2018 | 0 | 2 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Amino Acid Chloromethyl Ketones" by people in Profiles.
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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease. Biochem J. 2021 07 16; 478(13):2499-2515.
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Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects. Cell Rep. 2020 10 13; 33(2):108254.
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Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells. J Virol. 2018 10 01; 92(19).
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Juglone induces apoptosis and autophagy via modulation of mitogen-activated protein kinase pathways in human hepatocellular carcinoma cells. Food Chem Toxicol. 2018 Jun; 116(Pt B):40-50.
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Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells. Neurosci Lett. 2009 Aug 07; 459(2):47-51.
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Canine coronavirus induces apoptosis in cultured cells. Vet Microbiol. 2007 Mar 31; 121(1-2):64-72.
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The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13190-5.
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Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science. 2003 Jun 13; 300(5626):1763-7.
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Apoptosis-dependent acute lung injury and repair after intratracheal instillation of noradrenaline in rats. Exp Physiol. 2003 Mar; 88(2):269-75.
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Induction of caspase-dependent apoptosis in cultured cells by the avian coronavirus infectious bronchitis virus. J Virol. 2001 Jul; 75(14):6402-9.