"Melphalan" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
| Descriptor ID |
D008558
|
| MeSH Number(s) |
D02.455.526.728.650.594 D12.125.072.050.685.500
|
| Concept/Terms |
Melphalan- Melphalan
- L-PAM
- Phenylalanine Mustard
- Mustard, Phenylalanine
- 4-(Bis(2-chloroethyl)amino)phenylalanine
|
Below are MeSH descriptors whose meaning is more general than "Melphalan".
Below are MeSH descriptors whose meaning is more specific than "Melphalan".
This graph shows the total number of publications written about "Melphalan" by people in this website by year, and whether "Melphalan" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 2 | 0 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 4 | 5 | 9 |
| 2018 | 1 | 5 | 6 |
| 2019 | 2 | 1 | 3 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Melphalan" by people in Profiles.
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Mild and Severe SARS-CoV-2 Infection Induces Respiratory and Intestinal Microbiome Changes in the K18-hACE2 Transgenic Mouse Model. Microbiol Spectr. 2021 09 03; 9(1):e0053621.
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Cyclophosphamide plus etoposide is a safe and effective mobilization regimen in patients with multiple myeloma. Transfus Apher Sci. 2021 Oct; 60(5):103197.
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Management of patients with multiple myeloma during the COVID-19 pandemic. Lancet Haematol. 2020 06; 7(6):e435-e437.
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Impact of frailty, melphalan pharmacokinetics, and pharmacogenetics on outcomes post autologous hematopoietic cell transplantation for multiple myeloma. Bone Marrow Transplant. 2019 12; 54(12):2088-2095.
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High-dose therapy and autologous transplantation for POEMS Syndrome: effective, but how to optimise? Br J Haematol. 2019 09; 186(6):e178-e181.
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Fibrogenesis Imperfecta Ossium. Calcif Tissue Int. 2019 05; 104(5):561-569.
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Addition of melphalan to fludarabine/busulfan (FLU/BU4/MEL) provides survival benefit for patients with myeloid malignancy following allogeneic bone-marrow transplantation/peripheral blood stem-cell transplantation. Int J Hematol. 2019 Feb; 109(2):197-205.
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Pharmacokinetics and Exposure-Response Analyses of Daratumumab in Combination Therapy Regimens for Patients with Multiple Myeloma. Adv Ther. 2018 11; 35(11):1859-1872.
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Advances in POEMS treatment and the need to define standardised outcome measures. Br J Haematol. 2019 04; 185(2):386-388.
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Ophthalmic Vascular Events after Primary Unilateral Intra-arterial Chemotherapy for Retinoblastoma in Early and Recent Eras. Ophthalmology. 2018 11; 125(11):1803-1811.