Src Homology 2 Domain-Containing, Transforming Protein 1
"Src Homology 2 Domain-Containing, Transforming Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.
| Descriptor ID |
D000071425
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| MeSH Number(s) |
D12.644.360.024.330.500 D12.776.157.057.162.500 D12.776.476.024.424.500
|
| Concept/Terms |
Src Homology 2 Domain-Containing, Transforming Protein 1- Src Homology 2 Domain-Containing, Transforming Protein 1
- Src Homology 2 Domain Containing, Transforming Protein 1
- ShcA Protein
- SHC1 (Src Homology 2 Domain-Containing) Protein
- Src Homology 2 Domain-Containing-Transforming Protein C1
- Src Homology 2 Domain Containing Transforming Protein C1
- SHC (Src Homology 2 Domain-Containing) Transforming Protein 1
- SHC1 Protein
- SHC-Transforming Protein 1
- SHC Transforming Protein 1
|
Below are MeSH descriptors whose meaning is more general than "Src Homology 2 Domain-Containing, Transforming Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Src Homology 2 Domain-Containing, Transforming Protein 1".
This graph shows the total number of publications written about "Src Homology 2 Domain-Containing, Transforming Protein 1" by people in this website by year, and whether "Src Homology 2 Domain-Containing, Transforming Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 4 | 0 | 4 |
| 2019 | 2 | 0 | 2 |
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Below are the most recent publications written about "Src Homology 2 Domain-Containing, Transforming Protein 1" by people in Profiles.
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Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66Shc. Int J Mol Sci. 2019 Feb 24; 20(4).
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Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity. Eur Heart J. 2019 01 21; 40(4):383-391.
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Hyperglycaemia-induced epigenetic changes drive persistent cardiac dysfunction via the adaptor p66Shc. Int J Cardiol. 2018 Oct 01; 268:179-186.
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Interplay between gut microbiota and p66Shc affects obesity-associated insulin resistance. FASEB J. 2018 07; 32(7):4004-4015.
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Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance. Mol Cancer Res. 2018 05; 16(5):894-908.
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p66Shc gene expression in peripheral blood mononuclear cells and progression of diabetic complications. Cardiovasc Diabetol. 2018 01 17; 17(1):16.
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Impact of Glycemic Variability on Chromatin Remodeling, Oxidative Stress, and Endothelial Dysfunction in Patients With Type 2 Diabetes and With Target HbA1c Levels. Diabetes. 2017 09; 66(9):2472-2482.
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The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression. Nat Commun. 2017 03 09; 8:14638.
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Inhibition of ShcA isoforms p46/p52Shc enhances HIV-1 replication in CD4+ T-lymphocytes. J Cell Physiol. 2004 Apr; 199(1):40-6.