"Integrin alpha4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin alpha subunit that is unique in that it does not contain an I-domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane, as in other integrin alpha subunits.
| Descriptor ID |
D039441
|
| MeSH Number(s) |
D12.776.543.750.705.408.100.450
|
| Concept/Terms |
Integrin alpha4- Integrin alpha4
- CD49d Antigens
- Antigens, CD49d
- CD49d Antigen
- alpha4 Integrin
- Integrin, alpha4
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha4".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha4".
This graph shows the total number of publications written about "Integrin alpha4" by people in this website by year, and whether "Integrin alpha4" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin alpha4" by people in Profiles.
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Circulating Adaptive Immune Cells Expressing the Gut Homing Marker a4ß7 Integrin Are Decreased in COVID-19. Front Immunol. 2021; 12:639329.
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Covid-19 in a patient with multiple sclerosis treated with natalizumab: May the blockade of integrins have a protective role? Mult Scler Relat Disord. 2020 Sep; 44:102250.
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Overexpression of CD49d in trisomy 12 chronic lymphocytic leukemia patients is mediated by IRF4 through induction of IKAROS. Leukemia. 2019 05; 33(5):1278-1302.
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a4ß7+ CD4+ Effector/Effector Memory T Cells Differentiate into Productively and Latently Infected Central Memory T Cells by Transforming Growth Factor ß1 during HIV-1 Infection. J Virol. 2018 04 15; 92(8).
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Vedolizumab for the treatment of Crohn's disease. Expert Rev Clin Immunol. 2018 03; 14(3):179-189.
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Reversibility of the effects of natalizumab on peripheral immune cell dynamics in MS patients. Neurology. 2017 Oct 10; 89(15):1584-1593.
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Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on a4 integrin. Brain. 2011 Dec; 134(Pt 12):3560-77.
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Activation of leukocytes during the uteroplacental passage in preeclampsia. Hypertension. 2002 Jan; 39(1):155-60.