"Integrin alpha Chains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
| Descriptor ID |
D039001
|
| MeSH Number(s) |
D12.776.543.750.705.408.100
|
| Concept/Terms |
Integrin alpha Chains- Integrin alpha Chains
- alpha Chains, Integrin
- Integrin alpha Subunits
- alpha Integrins
- Integrins, alpha
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha Chains".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha Chains".
This graph shows the total number of publications written about "Integrin alpha Chains" by people in this website by year, and whether "Integrin alpha Chains" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 2 | 3 |
| 2018 | 3 | 0 | 3 |
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Below are the most recent publications written about "Integrin alpha Chains" by people in Profiles.
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Indeterminate pediatric acute liver failure is uniquely characterized by a CD103+ CD8+ T-cell infiltrate. Hepatology. 2018 09; 68(3):1087-1100.
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Forkhead box C1 promotes colorectal cancer metastasis through transactivating ITGA7 and FGFR4 expression. Oncogene. 2018 10; 37(41):5477-5491.
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Colonization-induced protection against invasive pneumococcal disease in mice is independent of CD103 driven adaptive immune responses. Eur J Immunol. 2018 06; 48(6):965-974.
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Detection of HIV-1-specific gastrointestinal tissue resident CD8+ T-cells in chronic infection. Mucosal Immunol. 2018 05; 11(3):909-920.
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Signaling pathway for phagocyte priming upon encounter with apoptotic cells. J Biol Chem. 2017 05 12; 292(19):8059-8072.
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Murine CD103+ dendritic cells protect against steatosis progression towards steatohepatitis. J Hepatol. 2017 06; 66(6):1241-1250.
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Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Sci Transl Med. 2016 10 26; 8(362):362ra143.