"Integrin alpha4beta1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
| Descriptor ID |
D039041
|
| MeSH Number(s) |
D12.776.395.550.200.625.347 D12.776.543.550.200.625.347 D12.776.543.750.705.408.530.500 D12.776.543.750.705.408.850.299 D12.776.543.750.705.877.347 D23.050.301.350.625.347
|
| Concept/Terms |
Integrin alpha4beta1- Integrin alpha4beta1
- alpha4beta1, Integrin
- VLA-4
- Integrin alpha(4)beta(1)
- alpha4beta1 Integrin
- Integrin, alpha4beta1
- Very Late Activation Antigen-4
- Very Late Activation Antigen 4
- Very Late Antigen-4
- Antigen-4, Very Late
- Late Antigen-4, Very
- Very Late Antigen 4
- CD49d-CD29
- Integrin Heterodimer alpha4beta1
- Heterodimer alpha4beta1, Integrin
- alpha4beta1, Integrin Heterodimer
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha4beta1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Glycoproteins [D12.776.395]
- Membrane Glycoproteins [D12.776.395.550]
- Cell Adhesion Molecules [D12.776.395.550.200]
- Receptors, Lymphocyte Homing [D12.776.395.550.200.625]
- Integrin alpha4beta1 [D12.776.395.550.200.625.347]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Cell Adhesion Molecules [D12.776.543.550.200]
- Receptors, Lymphocyte Homing [D12.776.543.550.200.625]
- Integrin alpha4beta1 [D12.776.543.550.200.625.347]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Integrins [D12.776.543.750.705.408]
- Receptors, Fibronectin [D12.776.543.750.705.408.530]
- Integrin alpha4beta1 [D12.776.543.750.705.408.530.500]
- Receptors, Very Late Antigen [D12.776.543.750.705.408.850]
- Integrin alpha4beta1 [D12.776.543.750.705.408.850.299]
- Receptors, Lymphocyte Homing [D12.776.543.750.705.877]
- Integrin alpha4beta1 [D12.776.543.750.705.877.347]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Cell Adhesion Molecules [D23.050.301.350]
- Receptors, Lymphocyte Homing [D23.050.301.350.625]
- Integrin alpha4beta1 [D23.050.301.350.625.347]
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha4beta1".
This graph shows the total number of publications written about "Integrin alpha4beta1" by people in this website by year, and whether "Integrin alpha4beta1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Integrin alpha4beta1" by people in Profiles.
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Dissecting Integrin Expression and Function on Memory B Cells in Mice and Humans in Autoimmunity. Front Immunol. 2019; 10:534.
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DS-70, a novel and potent a4 integrin antagonist, is an effective treatment for experimental allergic conjunctivitis in guinea pigs. Br J Pharmacol. 2018 10; 175(20):3891-3910.
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The a4ß1 Homing Pathway Is Essential for Ileal Homing of Crohn's Disease Effector T Cells In Vivo. Inflamm Bowel Dis. 2017 03; 23(3):379-391.
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Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow. Cancer Res. 2009 Apr 01; 69(7):3121-30.