Lymphocyte Function-Associated Antigen-1
"Lymphocyte Function-Associated Antigen-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
| Descriptor ID |
D016169
|
| MeSH Number(s) |
D12.776.395.550.200.074.937 D12.776.395.550.200.625.550 D12.776.543.550.200.093.937 D12.776.543.550.200.625.550 D12.776.543.750.705.408.600.400 D12.776.543.750.705.877.550 D23.050.301.350.074.400 D23.050.301.350.625.550
|
| Concept/Terms |
Lymphocyte Function-Associated Antigen-1- Lymphocyte Function-Associated Antigen-1
- Antigen-1, Lymphocyte Function-Associated
- Lymphocyte Function Associated Antigen 1
- Integrin alphaLbeta2
- alphaLbeta2, Integrin
- Leukocyte Function Associated Antigen-1
- LFA-1
|
Below are MeSH descriptors whose meaning is more general than "Lymphocyte Function-Associated Antigen-1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Glycoproteins [D12.776.395]
- Membrane Glycoproteins [D12.776.395.550]
- Cell Adhesion Molecules [D12.776.395.550.200]
- CD11 Antigens [D12.776.395.550.200.074]
- Lymphocyte Function-Associated Antigen-1 [D12.776.395.550.200.074.937]
- Receptors, Lymphocyte Homing [D12.776.395.550.200.625]
- Lymphocyte Function-Associated Antigen-1 [D12.776.395.550.200.625.550]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Cell Adhesion Molecules [D12.776.543.550.200]
- CD11 Antigens [D12.776.543.550.200.093]
- Lymphocyte Function-Associated Antigen-1 [D12.776.543.550.200.093.937]
- Receptors, Lymphocyte Homing [D12.776.543.550.200.625]
- Lymphocyte Function-Associated Antigen-1 [D12.776.543.550.200.625.550]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Integrins [D12.776.543.750.705.408]
- Receptors, Leukocyte-Adhesion [D12.776.543.750.705.408.600]
- Lymphocyte Function-Associated Antigen-1 [D12.776.543.750.705.408.600.400]
- Receptors, Lymphocyte Homing [D12.776.543.750.705.877]
- Lymphocyte Function-Associated Antigen-1 [D12.776.543.750.705.877.550]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Cell Adhesion Molecules [D23.050.301.350]
- CD11 Antigens [D23.050.301.350.074]
- Lymphocyte Function-Associated Antigen-1 [D23.050.301.350.074.400]
- Receptors, Lymphocyte Homing [D23.050.301.350.625]
- Lymphocyte Function-Associated Antigen-1 [D23.050.301.350.625.550]
Below are MeSH descriptors whose meaning is more specific than "Lymphocyte Function-Associated Antigen-1".
This graph shows the total number of publications written about "Lymphocyte Function-Associated Antigen-1" by people in this website by year, and whether "Lymphocyte Function-Associated Antigen-1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2017 | 0 | 3 | 3 |
| 2019 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Lymphocyte Function-Associated Antigen-1" by people in Profiles.
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Insight into the LFA-1/SARS-CoV-2 Orf7a Complex by Protein-Protein Docking, Molecular Dynamics, and MM-GBSA Calculations. J Chem Inf Model. 2021 06 28; 61(6):2780-2787.
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Structural assessment of SARS-CoV2 accessory protein ORF7a predicts LFA-1 and Mac-1 binding potential. Biosci Rep. 2021 01 29; 41(1).
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Dissecting Integrin Expression and Function on Memory B Cells in Mice and Humans in Autoimmunity. Front Immunol. 2019; 10:534.
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Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion. J Immunol. 2017 12 15; 199(12):4142-4154.
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High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors. Elife. 2017 09 06; 6.
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Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity. Blood. 2017 08 17; 130(7):847-858.
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Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow. Cancer Res. 2009 Apr 01; 69(7):3121-30.
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Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains. J Biomed Sci. 2006 May; 13(3):281-93.
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Intrahepatic alpha beta-TcRintermediate LFA-1high T cells are stimulated during mouse hepatitis viral infection. Adv Exp Med Biol. 1998; 440:479-83.
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Mouse hepatitis viral infection induces an extrathymic differentiation of the specific intrahepatic alpha beta-TCRintermediate LFA-1high T-cell population. Immunology. 1997 Mar; 90(3):402-11.