"Pyruvate Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.
Descriptor ID |
D011770
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MeSH Number(s) |
D08.811.913.696.620.695
|
Concept/Terms |
Pyruvate Kinase L- Pyruvate Kinase L
- L-Type Pyruvate Kinase
- L Type Pyruvate Kinase
- Pyruvate Kinase, L-Type
|
Below are MeSH descriptors whose meaning is more general than "Pyruvate Kinase".
Below are MeSH descriptors whose meaning is more specific than "Pyruvate Kinase".
This graph shows the total number of publications written about "Pyruvate Kinase" by people in this website by year, and whether "Pyruvate Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text,
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Year | Major Topic | Minor Topic | Total |
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2001 | 1 | 0 | 1 |
2017 | 6 | 0 | 6 |
2018 | 6 | 1 | 7 |
2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pyruvate Kinase" by people in Profiles.
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Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis. J Mol Biol. 2019 09 06; 431(19):3690-3705.
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Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation. Biochem J. 2018 10 31; 475(20):3275-3291.
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OsPKpa1 encodes a plastidic pyruvate kinase that affects starch biosynthesis in the rice endosperm. J Integr Plant Biol. 2018 Nov; 60(11):1097-1118.
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Discovery of genetic variants of the kinases that activate tenofovir among individuals in the United States, Thailand, and South Africa: HPTN067. PLoS One. 2018; 13(4):e0195764.
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Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study. Blood. 2018 05 17; 131(20):2183-2192.
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MicroRNA 130a Regulates both Hepatitis C Virus and Hepatitis B Virus Replication through a Central Metabolic Pathway. J Virol. 2018 04 01; 92(7).
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Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1a Transactivation in Steatohepatitis. Cell Metab. 2018 02 06; 27(2):339-350.e3.
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Pyruvate Kinase M2 Modulates the Glycolysis of Chondrocyte and Extracellular Matrix in Osteoarthritis. DNA Cell Biol. 2018 Mar; 37(3):271-277.
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Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis. Nat Commun. 2017 12 07; 8(1):1986.
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?-Alkynyl arachidonic acid promotes anti-inflammatory macrophage M2 polarization against acute myocardial infarction via regulating the cross-talk between PKM2, HIF-1a and iNOS. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Dec; 1862(12):1595-1605.