"Phosphofructokinase-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.
| Descriptor ID |
D025481
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| MeSH Number(s) |
D08.811.277.352.650.622 D08.811.641.843 D08.811.913.696.620.225.850.750
|
| Concept/Terms |
Phosphofructokinase-2- Phosphofructokinase-2
- Phosphofructokinase 2
- ATP-D-Fructose-6-phosphate 2-phosphotransferase
- 6-Phosphofructo-2-kinase
- Fructose-6-P,2-kinase
- Fructose-6-phosphate,2-kinase
- 6PF2K
- Fru-6-P,2-kinase
Fructose-2,6-bisphosphatase- Fructose-2,6-bisphosphatase
- Fructose-2,6-bisphosphate 2-phosphatase
- fructose-2,6-diphosphatase
- Fructose 2,6-bisphosphatase
6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase- 6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase
- 6-Phosphofructo 2-kinase-fructose 2,6-bisphosphatase
- Fructose-6-phosphate,2-kinase-fructose-2,6-bisphosphatase
- 6-PF-2-K-Fru-2,6-P(2)ase
- F Kinase-F-bisphosphatase
- Fru-kinase-Fru-bisphosphatase
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Below are MeSH descriptors whose meaning is more general than "Phosphofructokinase-2".
Below are MeSH descriptors whose meaning is more specific than "Phosphofructokinase-2".
This graph shows the total number of publications written about "Phosphofructokinase-2" by people in this website by year, and whether "Phosphofructokinase-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "Phosphofructokinase-2" by people in Profiles.
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IAPP toxicity activates HIF1a/PFKFB3 signaling delaying ß-cell loss at the expense of ß-cell function. Nat Commun. 2019 06 18; 10(1):2679.
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PFKFB2 Promoter Hypomethylation as Recurrence Predictive Marker in Well-Differentiated Thyroid Carcinomas. Int J Mol Sci. 2019 Mar 16; 20(6).