"PTEN Phosphohydrolase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.
| Descriptor ID |
D051059
|
| MeSH Number(s) |
D08.811.277.352.650.850 D12.776.476.590 D12.776.624.776.695
|
| Concept/Terms |
PTEN Phosphohydrolase- PTEN Phosphohydrolase
- Phosphohydrolase, PTEN
- PTEN Protein
- Phosphatase and Tensin Homologue on Chromosome Ten Protein
- PTEN Phosphatase
- Phosphatase, PTEN
- MMAC1 Protein
- PTEN Protein Phosphatase
- Phosphatase, PTEN Protein
- Protein Phosphatase, PTEN
- Mutated In Multiple Advanced Cancers 1 Protein
|
Below are MeSH descriptors whose meaning is more general than "PTEN Phosphohydrolase".
Below are MeSH descriptors whose meaning is more specific than "PTEN Phosphohydrolase".
This graph shows the total number of publications written about "PTEN Phosphohydrolase" by people in this website by year, and whether "PTEN Phosphohydrolase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 13 | 9 | 22 |
| 2018 | 11 | 9 | 20 |
| 2019 | 7 | 5 | 12 |
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Below are the most recent publications written about "PTEN Phosphohydrolase" by people in Profiles.
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The risk of pancreatic adenocarcinoma following SARS-CoV family infection. Sci Rep. 2021 06 21; 11(1):12948.
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Hallmarks of the aging T-cell system. FEBS J. 2021 12; 288(24):7123-7142.
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Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers. Cell Rep. 2019 08 27; 28(9):2317-2330.e8.
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Association between PTEN and clinical-pathological features of osteosarcoma. Biosci Rep. 2019 07 31; 39(7).
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Analyzing aggregation propensities of clinically relevant PTEN mutants: a new culprit in pathogenesis of cancer and other PTENopathies. J Biomol Struct Dyn. 2020 May; 38(8):2253-2266.
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Suppressive effect of microRNA-449a on the NDRG1/PTEN/AKT axis regulates endometrial cancer growth and metastasis. Exp Cell Res. 2019 09 15; 382(2):111468.
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Overexpression of tensin homolog deleted on chromosome ten (PTEN) by ciglitazone sensitizes doxorubicin-resistance leukemia cancer cells to treatment. J Cell Biochem. 2019 09; 120(9):15719-15729.
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PTEN immunohistochemistry in endometrial hyperplasia: which are the optimal criteria for the diagnosis of precancer? APMIS. 2019 Apr; 127(4):161-169.
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The Alcohol Extract of Coreopsis tinctoria Nutt Ameliorates Diabetes and Diabetic Nephropathy in db/db Mice through miR-192/miR-200b and PTEN/AKT and ZEB2/ECM Pathways. Biomed Res Int. 2019; 2019:5280514.
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PTEN Mutations Trigger Resistance to Immunotherapy. Trends Mol Med. 2019 06; 25(6):461-463.