"CLOCK Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
| Descriptor ID |
D056926
|
| MeSH Number(s) |
D08.811.913.050.134.415.500.049 D12.644.128.100 D12.776.189.200 D12.776.260.103.562 D12.776.930.125.562
|
| Concept/Terms |
CLOCK Proteins- CLOCK Proteins
- Circadian Locomotor Output Cycles Kaput Proteins
- CLOCK Protein
|
Below are MeSH descriptors whose meaning is more general than "CLOCK Proteins".
Below are MeSH descriptors whose meaning is more specific than "CLOCK Proteins".
This graph shows the total number of publications written about "CLOCK Proteins" by people in this website by year, and whether "CLOCK Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 3 | 0 | 3 |
| 2018 | 1 | 3 | 4 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "CLOCK Proteins" by people in Profiles.
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The circadian clock gene Bmal1: Role in COVID-19 and periodontitis. Chronobiol Int. 2021 06; 38(6):779-784.
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The Circadian Clock and Viral Infections. J Biol Rhythms. 2021 02; 36(1):9-22.
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Clock genes may drive seasonal variation in SARS-CoV-2 infectivity: are we due for a second wave of COVID-19 in the fall? J Biol Regul Homeost Agents. 2020 Jul-Aug,; 34(4):1455-1457.
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Spatiotemporal chromatin dynamics - A telltale of circadian epigenetic gene regulation. Life Sci. 2019 Mar 15; 221:377-391.
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[The rhythm of life]. Epidemiol Prev. 2018 Sep-Dec; 42(5-6):378-379.
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Circadian Rhythm of Glucocorticoid Administration Entrains Clock Genes in Immune Cells: A DREAM Trial Ancillary Study. J Clin Endocrinol Metab. 2018 08 01; 103(8):2998-3009.
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The Effect of Light Exposure at Night (LAN) on Carcinogenesis via Decreased Nocturnal Melatonin Synthesis. Molecules. 2018 May 29; 23(6).
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Clock genes alterations and endocrine disorders. Eur J Clin Invest. 2018 Jun; 48(6):e12927.
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Face and predictive validity of the Clock?19 mouse as an animal model for bipolar disorder: a systematic review. Mol Psychiatry. 2018 01; 23(1):70-80.
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Ramadan fasting in Saudi Arabia is associated with altered expression of CLOCK, DUSP and IL-1alpha genes, as well as changes in cardiometabolic risk factors. PLoS One. 2017; 12(4):e0174342.