Islet Amyloid Polypeptide
"Islet Amyloid Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pancreatic beta-cell hormone that is co-secreted with INSULIN. It displays an anorectic effect on nutrient metabolism by inhibiting gastric acid secretion, gastric emptying and postprandial GLUCAGON secretion. Islet amyloid polypeptide can fold into AMYLOID FIBRILS that have been found as a major constituent of pancreatic AMYLOID DEPOSITS.
| Descriptor ID |
D058228
|
| MeSH Number(s) |
D06.472.699.587.334 D12.644.548.586.234 D12.776.049.407.500
|
| Concept/Terms |
Islet Amyloid Polypeptide- Islet Amyloid Polypeptide
- Amyloid Polypeptide, Islet
- Polypeptide, Islet Amyloid
- Pancreatic Amylin
- Amylin, Pancreatic
- IAPP Protein
- Insulinoma Amyloid Polypeptide
- Amyloid Polypeptide, Insulinoma
- Polypeptide, Insulinoma Amyloid
- Amlintide
- Amylin
|
Below are MeSH descriptors whose meaning is more general than "Islet Amyloid Polypeptide".
Below are MeSH descriptors whose meaning is more specific than "Islet Amyloid Polypeptide".
This graph shows the total number of publications written about "Islet Amyloid Polypeptide" by people in this website by year, and whether "Islet Amyloid Polypeptide" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 2 | 0 | 2 |
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Below are the most recent publications written about "Islet Amyloid Polypeptide" by people in Profiles.
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IAPP toxicity activates HIF1a/PFKFB3 signaling delaying ß-cell loss at the expense of ß-cell function. Nat Commun. 2019 06 18; 10(1):2679.
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A contemporary biological pathway of islet amyloid polypeptide for the management of diabetic dementia. Chem Biol Interact. 2019 Jun 01; 306:117-122.
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hIAPP forms toxic oligomers in plasma. Chem Commun (Camb). 2018 May 24; 54(43):5426-5429.
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Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice. Sci Rep. 2018 01 18; 8(1):1116.
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Advances in Diabetes Pharmacotherapy: An Update for the Emergency Provider. J Emerg Med. 2018 Jan; 54(1):73-80.
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Self-assembly of a nine-residue amyloid-forming peptide fragment of SARS corona virus E-protein: mechanism of self aggregation and amyloid-inhibition of hIAPP. Biochemistry. 2015 Apr 07; 54(13):2249-2261.
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Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes. J Biol Chem. 2010 Jan 01; 285(1):339-48.