Amyloid beta-Protein Precursor
"Amyloid beta-Protein Precursor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.
| Descriptor ID |
D016564
|
| MeSH Number(s) |
D12.776.049.407.249 D12.776.543.039 D12.776.645.468.500 D12.776.811.050
|
| Concept/Terms |
Amyloid beta-Protein Precursor- Amyloid beta-Protein Precursor
- Amyloid beta Protein Precursor
- beta-Protein Precursor, Amyloid
- Amyloid beta Precursor Protein
- Protease Nexin II
- Nexin II, Protease
- beta-Amyloid Protein Precursor
- beta Amyloid Protein Precursor
- Protease Nexin 2
- Nexin 2, Protease
- Amyloid A4 Protein Precursor
- Amyloid Protein Precursor
|
Below are MeSH descriptors whose meaning is more general than "Amyloid beta-Protein Precursor".
Below are MeSH descriptors whose meaning is more specific than "Amyloid beta-Protein Precursor".
This graph shows the total number of publications written about "Amyloid beta-Protein Precursor" by people in this website by year, and whether "Amyloid beta-Protein Precursor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 7 | 8 | 15 |
| 2018 | 3 | 2 | 5 |
| 2019 | 1 | 2 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "Amyloid beta-Protein Precursor" by people in Profiles.
-
How secret conversations inside cells are transforming biology. Nature. 2019 03; 567(7747):162-164.
-
Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer's disease. J Neuroinflammation. 2019 Jan 05; 16(1):3.
-
Helix-Switch Enables C99 Dimer Transition between the Multiple Conformations. J Chem Inf Model. 2019 01 28; 59(1):339-350.
-
Early Activation of Astrocytes does not Affect Amyloid Plaque Load in an Animal Model of Alzheimer's Disease. Neurosci Bull. 2018 Dec; 34(6):912-920.
-
Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aß clearance. Free Radic Res. 2018 Dec; 52(11-12):1311-1322.
-
Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Hum Mol Genet. 2018 04 15; 27(8):1332-1342.
-
Plasma Biomarkers Predict Brain Amyloid-ß Burden. JAMA. 2018 Mar 13; 319(10):972.
-
Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Hum Mol Genet. 2018 01 01; 27(1):30-40.
-
Case-control analysis of leucine-rich repeat kinase 2 protective variants in Alzheimer's disease. Neurobiol Aging. 2018 04; 64:157.e7-157.e9.
-
Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 12 05; 114(49):13018-13023.