"Monocrotaline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.
| Descriptor ID |
D016686
|
| MeSH Number(s) |
D03.132.716.500 D03.633.100.772.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Monocrotaline".
Below are MeSH descriptors whose meaning is more specific than "Monocrotaline".
This graph shows the total number of publications written about "Monocrotaline" by people in this website by year, and whether "Monocrotaline" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 2 | 3 |
| 2018 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Monocrotaline" by people in Profiles.
-
Ca2+ handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy. J Mol Cell Cardiol. 2018 05; 118:208-224.
-
Intratracheal Administration of Autologous Bone Marrow-Derived Cells Ameliorates Monocrotaline-Induced Pulmonary Vessel Remodeling and Lung Inflammation in Rats. Lung. 2018 04; 196(2):147-155.
-
Expression of key enzymes in the mevalonate pathway are altered in monocrotaline-induced pulmonary arterial hypertension in rats. Mol Med Rep. 2017 Dec; 16(6):9593-9600.
-
Mesenchymal stromal cell therapy reduces lung inflammation and vascular remodeling and improves hemodynamics in experimental pulmonary arterial hypertension. Stem Cell Res Ther. 2017 10 03; 8(1):220.
-
Endothelial-to-mesenchymal transition in pulmonary hypertension. Circulation. 2015 Mar 17; 131(11):1006-18.