"Mice, Knockout" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
| Descriptor ID |
D018345
|
| MeSH Number(s) |
B01.050.050.136.500.500 B01.050.150.900.649.313.992.635.505.500.550.455 B01.050.150.900.649.313.992.635.505.500.800.500
|
| Concept/Terms |
Mice, Knockout- Mice, Knockout
- Mice, Knock-out
- Knock-out Mice
- Mice, Knock out
- Mouse, Knockout
- Knockout Mouse
- Knockout Mice
|
Below are MeSH descriptors whose meaning is more general than "Mice, Knockout".
Below are MeSH descriptors whose meaning is more specific than "Mice, Knockout".
This graph shows the total number of publications written about "Mice, Knockout" by people in this website by year, and whether "Mice, Knockout" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 6 | 6 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 4 | 4 |
| 2005 | 0 | 8 | 8 |
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 8 | 8 |
| 2008 | 0 | 9 | 9 |
| 2009 | 0 | 8 | 8 |
| 2010 | 0 | 13 | 13 |
| 2011 | 0 | 13 | 13 |
| 2012 | 0 | 11 | 11 |
| 2013 | 0 | 12 | 12 |
| 2014 | 0 | 9 | 9 |
| 2015 | 0 | 14 | 14 |
| 2016 | 0 | 20 | 20 |
| 2017 | 0 | 324 | 324 |
| 2018 | 1 | 266 | 267 |
| 2019 | 0 | 83 | 83 |
| 2020 | 0 | 15 | 15 |
| 2021 | 0 | 10 | 10 |
To return to the timeline, click here.
Below are the most recent publications written about "Mice, Knockout" by people in Profiles.
-
Inhibition of elastase enhances the adjuvanticity of alum and promotes anti-SARS-CoV-2 systemic and mucosal immunity. Proc Natl Acad Sci U S A. 2021 08 24; 118(34).
-
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation. Nat Commun. 2021 08 02; 12(1):4664.
-
CCR2 Regulates Vaccine-Induced Mucosal T-Cell Memory to Influenza A Virus. J Virol. 2021 07 12; 95(15):e0053021.
-
ACE2-lentiviral transduction enables mouse SARS-CoV-2 infection and mapping of receptor interactions. PLoS Pathog. 2021 07; 17(7):e1009723.
-
Gut ACE2 Expression, Tryptophan Deficiency, and Inflammatory Responses The Potential Connection That Should Not Be Ignored During SARS-CoV-2 Infection. Cell Mol Gastroenterol Hepatol. 2021; 12(4):1514-1516.e4.
-
Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways. PLoS Pathog. 2021 06; 17(6):e1009662.
-
CDCP1 on Dendritic Cells Contributes to the Development of a Model of Kawasaki Disease. J Immunol. 2021 06 15; 206(12):2819-2827.
-
Histone deficiency and accelerated replication stress in T cell aging. J Clin Invest. 2021 06 01; 131(11).
-
Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D. J Clin Invest. 2021 06 01; 131(11).
-
Toll-like Receptor-4 (TLR4) Agonist-Based Intranasal Nanovaccine Delivery System for Inducing Systemic and Mucosal Immunity. Mol Pharm. 2021 06 07; 18(6):2233-2241.