Platelet Glycoprotein GPIb-IX Complex
"Platelet Glycoprotein GPIb-IX Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.
Descriptor ID |
D019038
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MeSH Number(s) |
D12.776.395.550.625.460 D12.776.543.550.625.460 D12.776.543.750.705.675.568
|
Concept/Terms |
CD42c Antigens- CD42c Antigens
- Glycoprotein Ib beta
- CD42c Antigen
- Antigen, CD42c
- Antigens, CD42c
CD42b Antigens- CD42b Antigens
- Antigens, CD42b
- Glycoprotein Ib alpha
- CD42b Antigen
- Antigen, CD42b
CD42d Antigen- CD42d Antigen
- Antigen, CD42d
- CD42d Antigens
- Antigens, CD42d
|
Below are MeSH descriptors whose meaning is more general than "Platelet Glycoprotein GPIb-IX Complex".
Below are MeSH descriptors whose meaning is more specific than "Platelet Glycoprotein GPIb-IX Complex".
This graph shows the total number of publications written about "Platelet Glycoprotein GPIb-IX Complex" by people in this website by year, and whether "Platelet Glycoprotein GPIb-IX Complex" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2011 | 0 | 1 | 1 |
2014 | 1 | 0 | 1 |
2016 | 1 | 0 | 1 |
2017 | 2 | 2 | 4 |
2018 | 0 | 3 | 3 |
2019 | 2 | 0 | 2 |
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Below are the most recent publications written about "Platelet Glycoprotein GPIb-IX Complex" by people in Profiles.
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Immunothrombosis and thromboinflammation in host defense and disease. Platelets. 2021 Apr 03; 32(3):314-324.
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Membrane Protein of Human Coronavirus NL63 Is Responsible for Interaction with the Adhesion Receptor. J Virol. 2019 10 01; 93(19).
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Blood group alters platelet binding kinetics to von Willebrand factor and consequently platelet function. Blood. 2019 03 21; 133(12):1371-1377.
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Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis. Circulation. 2018 10 16; 138(16):1720-1735.
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Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets. Blood Adv. 2018 06 26; 2(12):1417-1428.
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The physical and cellular conditions of the human pulmonary circulation enable thrombopoiesis. Exp Hematol. 2018 07; 63:22-27.e3.
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Refrigeration-Induced Binding of von Willebrand Factor Facilitates Fast Clearance of Refrigerated Platelets. Arterioscler Thromb Vasc Biol. 2017 12; 37(12):2271-2279.
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Diagnosis or Exclusion of von Willebrand Disease Using Laboratory Testing. Methods Mol Biol. 2017; 1646:391-402.
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Laboratory Testing for von Willebrand Factor Activity by Glycoprotein Ib Binding Assays (VWF:GPIb). Methods Mol Biol. 2017; 1646:453-460.
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Ristocetin-Induced Platelet Aggregation (RIPA) and RIPA Mixing Studies. Methods Mol Biol. 2017; 1646:473-494.