Hepatocyte Nuclear Factor 4
"Hepatocyte Nuclear Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subfamily of nuclear receptors that regulate GENETIC TRANSCRIPTION of a diverse group of GENES involved in the synthesis of BLOOD COAGULATION FACTORS; and in GLUCOSE; CHOLESTEROL; and FATTY ACIDS metabolism.
| Descriptor ID |
D051557
|
| MeSH Number(s) |
D12.776.260.262.968 D12.776.660.352.968 D12.776.826.119 D12.776.930.318.968
|
| Concept/Terms |
Hepatocyte Nuclear Factor 4- Hepatocyte Nuclear Factor 4
- Hepatocyte Nuclear Factor-Forkhead Homolog 4
- Hepatocyte Nuclear Factor Forkhead Homolog 4
- HNF4 Transcription Factor
- Transcription Factor, HNF4
|
Below are MeSH descriptors whose meaning is more general than "Hepatocyte Nuclear Factor 4".
Below are MeSH descriptors whose meaning is more specific than "Hepatocyte Nuclear Factor 4".
This graph shows the total number of publications written about "Hepatocyte Nuclear Factor 4" by people in this website by year, and whether "Hepatocyte Nuclear Factor 4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 3 | 3 |
| 2011 | 1 | 0 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 3 | 3 | 6 |
| 2018 | 2 | 1 | 3 |
| 2019 | 2 | 0 | 2 |
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Below are the most recent publications written about "Hepatocyte Nuclear Factor 4" by people in Profiles.
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Intestinal Receptor of SARS-CoV-2 in Inflamed IBD Tissue Seems Downregulated by HNF4A in Ileum and Upregulated by Interferon Regulating Factors in Colon. J Crohns Colitis. 2021 Mar 05; 15(3):485-498.
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Identification of Transcription Factors Regulating SARS-CoV-2 Entry Genes in the Intestine. Cell Mol Gastroenterol Hepatol. 2021; 11(1):181-184.
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Generation of functional hepatocyte-like cells from human bone marrow mesenchymal stem cells by overexpression of transcription factor HNF4a and FOXA2. Hepatobiliary Pancreat Dis Int. 2019 Dec; 18(6):546-556.
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Dual Delivery of HNF4a and Cisplatin by Mesoporous Silica Nanoparticles Inhibits Cancer Pluripotency and Tumorigenicity in Hepatoma-Derived CD133-Expressing Stem Cells. ACS Appl Mater Interfaces. 2019 Jun 05; 11(22):19808-19818.
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HNF4alpha expression amplifies the glucocorticoid-induced conversion of a human pancreatic cell line to an hepatocyte-like cell. Biochem Biophys Res Commun. 2018 09 10; 503(3):1633-1640.
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Pharmacogenetics of the anti-HCV drug sofosbuvir: a preliminary study. J Antimicrob Chemother. 2018 06 01; 73(6):1659-1664.
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Cisplatin Enhances Hepatitis B Virus Replication and PGC-1a Expression through Endoplasmic Reticulum Stress. Sci Rep. 2018 02 22; 8(1):3496.
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Systematic integrative analysis of gene expression identifies HNF4A as the central gene in pathogenesis of non-alcoholic steatohepatitis. PLoS One. 2017; 12(12):e0189223.
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Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction. Sci Rep. 2017 11 30; 7(1):16675.
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Influence of ABCB11 and HNF4a genes on daclatasvir plasma concentration: preliminary pharmacogenetic data from the Kineti-C study. J Antimicrob Chemother. 2017 10 01; 72(10):2846-2849.