"Liver X Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nuclear receptors that bind OXYSTEROLS and function as heterodimers with RETINOID X RECEPTORS. They have important functions in regulating cholesterol homeostasis, ENERGY METABOLISM; INFLAMMATION; and the immune response.
| Descriptor ID |
D000071518
|
| MeSH Number(s) |
D12.776.260.531 D12.776.826.194
|
| Concept/Terms |
Liver X Receptors- Liver X Receptors
- Nuclear Oxysterol Receptors
- Oxysterol Receptors, Nuclear
- Liver X Receptor
Liver X Receptor Alpha- Liver X Receptor Alpha
- Liver X Receptor-Alpha
- NR1H3 Protein
- LXRalpha Protein
- Nuclear Orphan Receptor LXR-Alpha
- Nuclear Orphan Receptor LXR Alpha
- Oxysterols Receptor LXR-Alpha
- LXR-Alpha, Oxysterols Receptor
- Oxysterols Receptor LXR Alpha
- Nuclear Receptor Subfamily 1, Group H, Member 3
- LXR-Alpha Protein
- LXR Alpha Protein
Liver X Receptor Beta- Liver X Receptor Beta
- Liver X Receptor-Beta
- Nuclear Receptor Subfamily 1, Group H, Member 2
- Oxysterols Receptor LXR-Beta
- LXR-Beta, Oxysterols Receptor
- Oxysterols Receptor LXR Beta
- LXRbeta Protein
- NR1H2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Liver X Receptors".
Below are MeSH descriptors whose meaning is more specific than "Liver X Receptors".
This graph shows the total number of publications written about "Liver X Receptors" by people in this website by year, and whether "Liver X Receptors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 2 | 3 | 5 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Liver X Receptors" by people in Profiles.
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Activation of liver x receptors prevents the spinal LTP induced by skin/muscle retraction in the thigh via SIRT1/NF-?b pathway. Neurochem Int. 2019 09; 128:106-114.
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DEL-1 promotes macrophage efferocytosis and clearance of inflammation. Nat Immunol. 2019 01; 20(1):40-49.
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Ginsenoside 25-OCH3-PPD Promotes Activity of LXRs To Ameliorate P2X7R-Mediated NLRP3 Inflammasome in the Development of Hepatic Fibrosis. J Agric Food Chem. 2018 Jul 11; 66(27):7023-7035.
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Mindin deficiency in macrophages protects against foam cell formation and atherosclerosis by targeting LXR-ß. Clin Sci (Lond). 2018 06 15; 132(11):1199-1213.
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Vitexin inhibits Aß25-35 induced toxicity in Neuro-2a cells by augmenting Nrf-2/HO-1 dependent antioxidant pathway and regulating lipid homeostasis by the activation of LXR-a. Toxicol In Vitro. 2018 Aug; 50:160-171.
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Interleukin-32 upregulates the expression of ABCA1 and ABCG1 resulting in reduced intracellular lipid concentrations in primary human hepatocytes. Atherosclerosis. 2018 04; 271:193-202.
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Phytosterol-mediated inhibition of intestinal cholesterol absorption in mice is independent of liver X receptor. Mol Nutr Food Res. 2017 09; 61(9).
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A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes. Nat Commun. 2017 01 27; 8:14147.
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SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Cell Metab. 2017 02 07; 25(2):412-427.
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Liver X receptor activation attenuates plaque formation and improves vasomotor function of the aortic artery in atherosclerotic ApoE(-/-) mice. Inflamm Res. 2012 Dec; 61(12):1299-307.