"Morpholinos" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Synthetic analogs of NUCLEIC ACIDS composed of morpholine ring derivatives (MORPHOLINES) linked by phosphorodimidates. One standard DNA nucleic acid base (ADENINE; GUANINE; CYTOSINE; OR THYMINE) is bound to each morpholine ring.
| Descriptor ID |
D060172
|
| MeSH Number(s) |
D03.383.533.640.562 D13.695.578.424.337
|
| Concept/Terms |
Morpholinos- Morpholinos
- Morpholino Oligonucleotides
- Oligonucleotides, Morpholino
- Phosphorodiamidate Morpholino Oligomers
- Morpholino Oligomers, Phosphorodiamidate
- Oligomers, Phosphorodiamidate Morpholino
- PMO Oligomers
- Oligomers, PMO
- Morpholino Oligos
- Oligos, Morpholino
- MORF Oligomers
- Oligomers, MORF
|
Below are MeSH descriptors whose meaning is more general than "Morpholinos".
Below are MeSH descriptors whose meaning is more specific than "Morpholinos".
This graph shows the total number of publications written about "Morpholinos" by people in this website by year, and whether "Morpholinos" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Morpholinos" by people in Profiles.
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Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers. Nat Commun. 2021 07 20; 12(1):4396.
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Rapid and unamplified identification of COVID-19 with morpholino-modified graphene field-effect transistor nanosensor. Biosens Bioelectron. 2021 Jul 01; 183:113206.
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Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino oligomers. J Antimicrob Chemother. 2021 01 19; 76(2):413-417.
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Centrosomal protein FOR20 is essential for cilia-dependent development in zebrafish embryos. FASEB J. 2019 03; 33(3):3613-3622.
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Morpholino-based correction of hypomorphic ZAP70 mutation in an adult with combined immunodeficiency. J Allergy Clin Immunol. 2017 05; 139(5):1688-1692.e10.
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Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity. J Virol. 2009 Mar; 83(5):2298-309.
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Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers. J Virol. 2005 Aug; 79(15):9665-76.
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Antisense morpholino-oligomers directed against the 5' end of the genome inhibit coronavirus proliferation and growth. J Virol. 2004 Jun; 78(11):5891-9.