"Microglia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
| Descriptor ID |
D017628
|
| MeSH Number(s) |
A08.637.400 A11.650.400
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Microglia".
Below are MeSH descriptors whose meaning is more specific than "Microglia".
This graph shows the total number of publications written about "Microglia" by people in this website by year, and whether "Microglia" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 18 | 10 | 28 |
| 2018 | 14 | 9 | 23 |
| 2019 | 0 | 3 | 3 |
| 2020 | 3 | 0 | 3 |
| 2021 | 2 | 2 | 4 |
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Below are the most recent publications written about "Microglia" by people in Profiles.
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COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital. Brain. 2021 10 22; 144(9):2696-2708.
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Expression of SARS-CoV-2-related receptors in cells of the neurovascular unit: implications for HIV-1 infection. J Neuroinflammation. 2021 Jul 29; 18(1):167.
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The Influence of Virus Infection on Microglia and Accelerated Brain Aging. Cells. 2021 07 20; 10(7).
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Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19. Genome Med. 2021 07 19; 13(1):118.
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Anti-inflammatory Therapy by Cholinergic and Purinergic Modulation in Multiple Sclerosis Associated with SARS-CoV-2 Infection. Mol Neurobiol. 2021 Oct; 58(10):5090-5111.
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NLRP3 and Infections: ß-Amyloid in Inflammasome beyond Neurodegeneration. Int J Mol Sci. 2021 Jun 29; 22(13).
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Potentials to alleviate coagulopathy and enhance microglial function of beta (ß)- glucans, making them worth a clinical study for COVID-19's neurological sequalae. J Neurol Sci. 2021 08 15; 427:117554.
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Dysregulation of brain and choroid plexus cell types in severe COVID-19. Nature. 2021 07; 595(7868):565-571.
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COVID-19-related neuropathology and microglial activation in elderly with and without dementia. Brain Pathol. 2021 09; 31(5):e12997.
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Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions. Immunity. 2021 07 13; 54(7):1594-1610.e11.