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Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity. 2021 07 13; 54(7):1463-1477.e11.
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PubMed
subject areas
Adenosine Triphosphate
Animals
Cytokines
DNA, Mitochondrial
Humans
Inflammasomes
Interleukin-1beta
Lipopolysaccharides
Metformin
Mice
NLR Family, Pyrin Domain-Containing 3 Protein
Nucleoside-Phosphate Kinase
Pneumonia
authors with profiles
Moshe Arditi
Raphaella Gatchalian
Elsa Sanchez-Lopez
Michael Karin
Melissa Luevanos
Hongxu Xian
Alexandra Rundberg Nilsson
Pejman Soroosh
Gavin Lewis
Timothy R Crother
Warren G Tourtellotte
Juan Carlos de la Torre
Stuart A Lipton
John R Teijaro
Dorit Trudler
Yuan Liu
Yi Zhang
Weixuan Chen
German R Aleman-Muench
Sarah Kang