"Toll-Like Receptor 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pattern recognition receptor that binds DOUBLE-STRANDED RNA. It mediates cellular responses to certain viral pathogens.
| Descriptor ID |
D051196
|
| MeSH Number(s) |
D12.776.543.750.705.910.500.300
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Toll-Like Receptor 3".
Below are MeSH descriptors whose meaning is more specific than "Toll-Like Receptor 3".
This graph shows the total number of publications written about "Toll-Like Receptor 3" by people in this website by year, and whether "Toll-Like Receptor 3" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2015 | 3 | 0 | 3 |
| 2016 | 0 | 1 | 1 |
| 2017 | 9 | 6 | 15 |
| 2018 | 8 | 1 | 9 |
| 2019 | 2 | 1 | 3 |
| 2020 | 0 | 2 | 2 |
| 2021 | 4 | 1 | 5 |
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Below are the most recent publications written about "Toll-Like Receptor 3" by people in Profiles.
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Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patients. Sci Rep. 2021 07 27; 11(1):15223.
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Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19. J Clin Invest. 2021 07 15; 131(14).
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Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection. J Biol Chem. 2021 08; 297(2):100925.
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N-acylethanolamine regulation of TLR3-induced hyperthermia and neuroinflammatory gene expression: A role for PPARa. J Neuroimmunol. 2021 09 15; 358:577654.
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SARS-CoV-2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING signaling pathways. J Med Virol. 2021 09; 93(9):5376-5389.
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COVID-19 and hypertension: Is there a role for dsRNA and activation of Toll-like receptor 3? Vascul Pharmacol. 2021 10; 140:106861.
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TLR3 (rs3775291) variant is not associated with SARS-CoV-2 infection and related mortality: a population-based correlation analysis. Hum Cell. 2021 Jul; 34(4):1274-1277.
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Low Doses of Radiation Increase the Immunosuppressive Profile of Lung Macrophages During Viral Infection and Pneumonia. Int J Radiat Oncol Biol Phys. 2021 08 01; 110(5):1283-1294.
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Association of TLR3 functional variant (rs3775291) with COVID-19 susceptibility and death: a population-scale study. Hum Cell. 2021 May; 34(3):1025-1027.
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IFN-a2a Therapy in Two Patients with Inborn Errors of TLR3 and IRF3 Infected with SARS-CoV-2. J Clin Immunol. 2021 01; 41(1):26-27.