"Toll-Like Receptor 8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pattern recognition receptor that recognizes GUANOSINE and URIDINE-rich single-stranded RNA.
| Descriptor ID |
D051200
|
| MeSH Number(s) |
D12.776.543.750.705.910.500.800
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Toll-Like Receptor 8".
Below are MeSH descriptors whose meaning is more specific than "Toll-Like Receptor 8".
This graph shows the total number of publications written about "Toll-Like Receptor 8" by people in this website by year, and whether "Toll-Like Receptor 8" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 2 | 3 |
| 2018 | 7 | 1 | 8 |
| 2019 | 0 | 1 | 1 |
| 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "Toll-Like Receptor 8" by people in Profiles.
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Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll-like receptors 7 and 8. Pharmacol Res Perspect. 2021 10; 9(5):e00842.
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In-silico immunoinformatic analysis of SARS-CoV-2 virus for the development of putative vaccine construct. Immunobiology. 2021 09; 226(5):152134.
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Role of toll-like receptor 7/8 pathways in regulation of interferon response and inflammatory mediators during SARS-CoV2 infection and potential therapeutic options. Biomed Pharmacother. 2021 Sep; 141:111794.
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TLR7 Ligation Inhibits TLR8 Responsiveness in IL-27-Primed Human THP-1 Monocytes and Macrophages. J Innate Immun. 2021; 13(6):345-358.
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Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine*. Angew Chem Int Ed Engl. 2021 04 19; 60(17):9467-9473.
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Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBV152: a double-blind, randomised, phase 1 trial. Lancet Infect Dis. 2021 05; 21(5):637-646.
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A survey of genetic variants in SARS-CoV-2 interacting domains of ACE2, TMPRSS2 and TLR3/7/8 across populations. Infect Genet Evol. 2020 11; 85:104507.
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Bioinformatic analysis and identification of single-stranded RNA sequences recognized by TLR7/8 in the SARS-CoV-2, SARS-CoV, and MERS-CoV genomes. Microbes Infect. 2020 May - Jun; 22(4-5):226-229.
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Immunoinformatics approaches for designing a novel multi epitope peptide vaccine against human norovirus (Norwalk virus). Infect Genet Evol. 2019 10; 74:103936.
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Lymph-Node-Targeted Immune Activation by Engineered Block Copolymer Amphiphiles-TLR7/8 Agonist Conjugates. J Am Chem Soc. 2018 10 31; 140(43):14300-14307.