Zhiyong Lou

InstitutionTsinghua University
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 11 Covid-19 publications, with a maximum of 3 publications in May 2021
    All Publications
    Bar chart showing 124 publications over 19 distinct years, with a maximum of 14 publications in 2009
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

    To see the data from both graphs as text, click here.
    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
    Sort By:     Newest   |   Oldest   |   Most Cited   |   Most Discussed
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stern-Ginossar N, Kanneganti TD, Cameron CE, Lou Z, Cherry S, Abraham J, Martin-Sancho L. Rising to the challenge of COVID-19: Working on SARS-CoV-2 during the pandemic. Mol Cell. 2021 06 03; 81(11):2261-2265. PMID: 34087174.
      Citations:    Fields:    Translation:HumansPHPublic Health
    2. Yan L, Yang Y, Li M, Zhang Y, Zheng L, Ge J, Huang YC, Liu Z, Wang T, Gao S, Zhang R, Huang YY, Guddat LW, Gao Y, Rao Z, Lou Z. Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. Cell. 2021 06 24; 184(13):3474-3485.e11. PMID: 34143953.
      Citations: 11     Fields:    Translation:HumansCells
    3. Guo Y, Huang L, Zhang G, Yao Y, Zhou H, Shen S, Shen B, Li B, Li X, Zhang Q, Chen M, Chen D, Wu J, Fu D, Zeng X, Feng M, Pi C, Wang Y, Zhou X, Lu M, Li Y, Fang Y, Lu YY, Hu X, Wang S, Zhang W, Gao G, Adrian F, Wang Q, Yu F, Peng Y, Gabibov AG, Min J, Wang Y, Huang H, Stepanov A, Zhang W, Cai Y, Liu J, Yuan Z, Zhang C, Lou Z, Deng F, Zhang H, Shan C, Schweizer L, Sun K, Rao Z. A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. Nat Commun. 2021 05 11; 12(1):2623. PMID: 33976198.
      Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    4. Fu D, Zhang G, Wang Y, Zhang Z, Hu H, Shen S, Wu J, Li B, Li X, Fang Y, Liu J, Wang Q, Zhou Y, Wang W, Li Y, Lu Z, Wang X, Nie C, Tian Y, Chen D, Wang Y, Zhou X, Wang Q, Yu F, Zhang C, Deng C, Zhou L, Guan G, Shao N, Lou Z, Deng F, Zhang H, Chen X, Wang M, Liu L, Rao Z, Guo Y. Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes. PLoS Biol. 2021 05; 19(5):e3001209. PMID: 33961621.
      Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    5. Zhou X, Wang H, Ji Q, Du M, Liang Y, Li H, Li F, Shang H, Zhu X, Wang W, Jiang L, Stepanov AV, Ma T, Gong N, Jia X, Gabibov AG, Lou Z, Lu Y, Guo Y, Zhang H, Yang X. Molecular deconvolution of the neutralizing antibodies induced by an inactivated SARS-CoV-2 virus vaccine. Protein Cell. 2021 10; 12(10):818-823. PMID: 33909239.
      Citations: 2     Fields:    Translation:Humans
    6. Yan L, Zhang Y, Ge J, Zheng L, Gao Y, Wang T, Jia Z, Wang H, Huang Y, Li M, Wang Q, Rao Z, Lou Z. Architecture of a SARS-CoV-2 mini replication and transcription complex. Nat Commun. 2020 11 18; 11(1):5874. PMID: 33208736.
      Citations: 37     Fields:    Translation:HumansCells
    7. Yan L, Ge J, Zheng L, Zhang Y, Gao Y, Wang T, Huang Y, Yang Y, Gao S, Li M, Liu Z, Wang H, Li Y, Chen Y, Guddat LW, Wang Q, Rao Z, Lou Z. Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. Cell. 2021 01 07; 184(1):184-193.e10. PMID: 33232691.
      Citations: 38     Fields:    Translation:Cells
    8. Xia S, Zhang Y, Wang Y, Wang H, Yang Y, Gao GF, Tan W, Wu G, Xu M, Lou Z, Huang W, Xu W, Huang B, Wang H, Wang W, Zhang W, Li N, Xie Z, Ding L, You W, Zhao Y, Yang X, Liu Y, Wang Q, Huang L, Yang Y, Xu G, Luo B, Wang W, Liu P, Guo W, Yang X. Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial. Lancet Infect Dis. 2021 01; 21(1):39-51. PMID: 33069281.
      Citations: 209     Fields:    Translation:HumansCTClinical Trials
    9. Wang H, Zhang Y, Huang B, Deng W, Quan Y, Wang W, Xu W, Zhao Y, Li N, Zhang J, Liang H, Bao L, Xu Y, Ding L, Zhou W, Gao H, Liu J, Niu P, Zhao L, Zhen W, Fu H, Yu S, Zhang Z, Xu G, Li C, Lou Z, Xu M, Qin C, Wu G, Gao GF, Tan W, Yang X. Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2. Cell. 2020 08 06; 182(3):713-721.e9. PMID: 32778225.
      Citations: 198     Fields:    Translation:AnimalsCellsPHPublic Health
    10. Wang Q, Wu J, Wang H, Gao Y, Liu Q, Mu A, Ji W, Yan L, Zhu Y, Zhu C, Fang X, Yang X, Huang Y, Gao H, Liu F, Ge J, Sun Q, Yang X, Xu W, Liu Z, Yang H, Lou Z, Jiang B, Guddat LW, Gong P, Rao Z. Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase. Cell. 2020 07 23; 182(2):417-428.e13. PMID: 32526208.
      Citations: 123     Fields:    Translation:Cells
    11. Gao Y, Yan L, Huang Y, Liu F, Zhao Y, Cao L, Wang T, Sun Q, Ming Z, Zhang L, Ge J, Zheng L, Zhang Y, Wang H, Zhu Y, Zhu C, Hu T, Hua T, Zhang B, Yang X, Li J, Yang H, Liu Z, Xu W, Guddat LW, Wang Q, Lou Z, Rao Z. Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science. 2020 05 15; 368(6492):779-782. PMID: 32277040.
      Citations: 408     Fields:    Translation:Cells
    12. Jia Z, Yan L, Ren Z, Wu L, Wang J, Guo J, Zheng L, Ming Z, Zhang L, Lou Z, Rao Z. Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis. Nucleic Acids Res. 2019 07 09; 47(12):6538-6550. PMID: 31131400.
      Citations: 94     Fields:    Translation:Cells
    13. Zhang L, Li L, Yan L, Ming Z, Jia Z, Lou Z, Rao Z. Structural and Biochemical Characterization of Endoribonuclease Nsp15 Encoded by Middle East Respiratory Syndrome Coronavirus. J Virol. 2018 11 15; 92(22). PMID: 30135128.
      Citations: 30     Fields:    Translation:HumansCells
    14. Ma Y, Wu L, Shaw N, Gao Y, Wang J, Sun Y, Lou Z, Yan L, Zhang R, Rao Z. Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):9436-41. PMID: 26159422.
      Citations: 144     Fields:    Translation:Cells
    15. Kong L, Shaw N, Yan L, Lou Z, Rao Z. Structural view and substrate specificity of papain-like protease from avian infectious bronchitis virus. J Biol Chem. 2015 Mar 13; 290(11):7160-8. PMID: 25609249.
      Citations: 9     Fields:    Translation:AnimalsCells
    16. Lou Z, Sun Y, Rao Z. Current progress in antiviral strategies. Trends Pharmacol Sci. 2014 Feb; 35(2):86-102. PMID: 24439476.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    17. Ren Z, Yan L, Zhang N, Guo Y, Yang C, Lou Z, Rao Z. The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease. Protein Cell. 2013 Apr; 4(4):248-50. PMID: 23549610.
      Citations: 57     Fields:    Translation:HumansCells
    18. Yu K, Ming Z, Li Y, Chen C, Bao Z, Ren Z, Liu B, Tao W, Rao Z, Lou Z. Purification, crystallization and preliminary X-ray analysis of nonstructural protein 2 (nsp2) from avian infectious bronchitis virus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 01; 68(Pt 6):716-9. PMID: 22684079.
      Citations: 4     Fields:    Translation:Cells
    19. Ma Y, Tong X, Xu X, Li X, Lou Z, Rao Z. Structures of the N- and C-terminal domains of MHV-A59 nucleocapsid protein corroborate a conserved RNA-protein binding mechanism in coronavirus. Protein Cell. 2010 Jul; 1(7):688-97. PMID: 21203940.
      Citations: 24     Fields:    Translation:Cells
    20. Zhang S, Zhong N, Xue F, Kang X, Ren X, Chen J, Jin C, Lou Z, Xia B. Three-dimensional domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease. Protein Cell. 2010 Apr; 1(4):371-383. PMID: 21203949.
      Citations: 20     Fields:    Translation:HumansCells
    21. Xu X, Lou Z, Ma Y, Chen X, Yang Z, Tong X, Zhao Q, Xu Y, Deng H, Bartlam M, Rao Z. Crystal structure of the C-terminal cytoplasmic domain of non-structural protein 4 from mouse hepatitis virus A59. PLoS One. 2009 Jul 10; 4(7):e6217. PMID: 19593433.
      Citations: 6     Fields:    Translation:AnimalsCells
    22. Zhong N, Zhang S, Xue F, Kang X, Zou P, Chen J, Liang C, Rao Z, Jin C, Lou Z, Xia B. C-terminal domain of SARS-CoV main protease can form a 3D domain-swapped dimer. Protein Sci. 2009 Apr; 18(4):839-44. PMID: 19319935.
      Citations: 14     Fields:    Translation:HumansCells
    23. Su D, Lou Z, Sun F, Zhai Y, Yang H, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z. Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10. J Virol. 2006 Aug; 80(16):7902-8. PMID: 16873247.
      Citations: 59     Fields:    Translation:Cells
    24. Xu X, Zhai Y, Sun F, Lou Z, Su D, Xu Y, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z. New antiviral target revealed by the hexameric structure of mouse hepatitis virus nonstructural protein nsp15. J Virol. 2006 Aug; 80(16):7909-17. PMID: 16873248.
      Citations: 45     Fields:    Translation:Cells
    25. Xu Y, Zhu J, Liu Y, Lou Z, Yuan F, Liu Y, Cole DK, Ni L, Su N, Qin L, Li X, Bai Z, Bell JI, Pang H, Tien P, Gao GF, Rao Z. Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus. Biochemistry. 2004 Nov 09; 43(44):14064-71. PMID: 15518555.
      Citations: 27     Fields:    Translation:Cells
    26. Xu Y, Cole DK, Lou Z, Liu Y, Qin L, Li X, Bai Z, Yuan F, Rao Z, Gao GF. Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein. Protein Expr Purif. 2004 Nov; 38(1):116-22. PMID: 15477089.
      Citations: 3     Fields:    Translation:Cells
    27. Xu Y, Lou Z, Liu Y, Pang H, Tien P, Gao GF, Rao Z. Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core. J Biol Chem. 2004 Nov 19; 279(47):49414-9. PMID: 15345712.
      Citations: 100     Fields:    Translation:Cells
    28. Xu Y, Liu Y, Lou Z, Qin L, Li X, Bai Z, Pang H, Tien P, Gao GF, Rao Z. Structural basis for coronavirus-mediated membrane fusion. Crystal structure of mouse hepatitis virus spike protein fusion core. J Biol Chem. 2004 Jul 16; 279(29):30514-22. PMID: 15123674.
      Citations: 65     Fields:    Translation:AnimalsCells
    29. Yang H, Yang M, Ding Y, Liu Y, Lou Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, Gao GF, Anand K, Bartlam M, Hilgenfeld R, Rao Z. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13190-5. PMID: 14585926.
      Citations: 375     Fields:    Translation:Cells
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