Mark R Denison

InstitutionVanderbilt University Medical Center
AddressNashville
Tennessee
United States
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 12 Covid-19 publications, with a maximum of 2 publications in July 2020 and December 2020
    All Publications
    Bar chart showing 81 publications over 19 distinct years, with a maximum of 8 publications in 2020
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

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    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pegu A, O'Connell SE, Schmidt SD, O'Dell S, Talana CA, Lai L, Albert J, Anderson E, Bennett H, Corbett KS, Flach B, Jackson L, Leav B, Ledgerwood JE, Luke CJ, Makowski M, Nason MC, Roberts PC, Roederer M, Rebolledo PA, Rostad CA, Rouphael NG, Shi W, Wang L, Widge AT, Yang ES, Beigel JH, Graham BS, Mascola JR, Suthar MS, McDermott AB, Doria-Rose NA, Arega J, Beigel JH, Buchanan W, Elsafy M, Hoang B, Lampley R, Kolhekar A, Koo H, Luke C, Makhene M, Nayak S, Pikaart-Tautges R, Roberts PC, Russell J, Sindall E, Albert J, Kunwar P, Makowski M, Anderson EJ, Bechnak A, Bower M, Camacho-Gonzalez AF, Collins M, Drobeniuc A, Edara VV, Edupuganti S, Floyd K, Gibson T, Ackerley CMG, Johnson B, Kamidani S, Kao C, Kelley C, Lai L, Macenczak H, McCullough MP, Peters E, Phadke VK, Rebolledo PA, Rostad CA, Rouphael N, Scherer E, Sherman A, Stephens K, Suthar MS, Teherani M, Traenkner J, et al. Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants. Science. 2021 09 17; 373(6561):1372-1377. PMID: 34385356.
      Citations: 34     Fields:    Translation:Humans
    2. Self WH, Stewart TG, Wheeler AP, El Atrouni W, Bistran-Hall AJ, Casey JD, Cataldo VD, Chappell JD, Cohn CS, Collins JB, Denison MR, de Wit M, Dixon SL, Duggal A, Edwards TL, Fontaine MJ, Ginde AA, Harkins MS, Harrington T, Harris ES, Hoda D, Ipe TS, Jaiswal SJ, Johnson NJ, Jones AE, Laguio-Vila M, Lindsell CJ, Mallada J, Mammen MJ, Metcalf RA, Middleton EA, Mucha S, O'Neal HR, Pannu SR, Pulley JM, Qiao X, Raval JS, Rhoads JP, Schrager H, Shanholtz C, Shapiro NI, Schrantz SJ, Thomsen I, Vermillion KK, Bernard GR, Rice TW. Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults. Trials. 2021 Mar 20; 22(1):221. PMID: 33743799.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    3. Chiotos K, Hayes M, Kimberlin DW, Jones SB, James SH, Pinninti SG, Yarbrough A, Abzug MJ, MacBrayne CE, Soma VL, Dulek DE, Vora SB, Waghmare A, Wolf J, Olivero R, Grapentine S, Wattier RL, Bio L, Cross SJ, Dillman NO, Downes KJ, Oliveira CR, Timberlake K, Young J, Orscheln RC, Tamma PD, Schwenk HT, Zachariah P, Aldrich ML, Goldman DL, Groves HE, Rajapakse NS, Lamb GS, Tribble AC, Hersh AL, Thorell EA, Denison MR, Ratner AJ, Newland JG, Nakamura MM. Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2. J Pediatric Infect Dis Soc. 2021 Feb 13; 10(1):34-48. PMID: 32918548.
      Citations: 15     Fields:    Translation:Humans
    4. Gribble J, Stevens LJ, Agostini ML, Anderson-Daniels J, Chappell JD, Lu X, Pruijssers AJ, Routh AL, Denison MR. The coronavirus proofreading exoribonuclease mediates extensive viral recombination. PLoS Pathog. 2021 01; 17(1):e1009226. PMID: 33465137.
      Citations: 34     Fields:    Translation:Humans
    5. Chiotos K, Hayes M, Kimberlin DW, Jones SB, James SH, Pinninti SG, Yarbrough A, Abzug MJ, MacBrayne CE, Soma VL, Dulek DE, Vora SB, Waghmare A, Wolf J, Olivero R, Grapentine S, Wattier RL, Bio L, Cross SJ, Dillman NO, Downes KJ, Timberlake K, Young J, Orscheln RC, Tamma PD, Schwenk HT, Zachariah P, Aldrich M, Goldman DL, Groves HE, Lamb GS, Tribble AC, Hersh AL, Thorell EA, Denison MR, Ratner AJ, Newland JG, Nakamura MM. Multicenter Initial Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2. J Pediatric Infect Dis Soc. 2020 Dec 31; 9(6):701-715. PMID: 32318706.
      Citations: 43     Fields:    Translation:Humans
    6. Citations: 199     Fields:    Translation:HumansCells
    7. Citations: 343     Fields:    Translation:HumansCellsCTClinical Trials
    8. Corbett KS, Edwards DK, Leist SR, Abiona OM, Boyoglu-Barnum S, Gillespie RA, Himansu S, Schäfer A, Ziwawo CT, DiPiazza AT, Dinnon KH, Elbashir SM, Shaw CA, Woods A, Fritch EJ, Martinez DR, Bock KW, Minai M, Nagata BM, Hutchinson GB, Wu K, Henry C, Bahl K, Garcia-Dominguez D, Ma L, Renzi I, Kong WP, Schmidt SD, Wang L, Zhang Y, Phung E, Chang LA, Loomis RJ, Altaras NE, Narayanan E, Metkar M, Presnyak V, Liu C, Louder MK, Shi W, Leung K, Yang ES, West A, Gully KL, Stevens LJ, Wang N, Wrapp D, Doria-Rose NA, Stewart-Jones G, Bennett H, Alvarado GS, Nason MC, Ruckwardt TJ, McLellan JS, Denison MR, Chappell JD, Moore IN, Morabito KM, Mascola JR, Baric RS, Carfi A, Graham BS. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness. Nature. 2020 10; 586(7830):567-571. PMID: 32756549.
      Citations: 291     Fields:    Translation:AnimalsCellsPHPublic Health
    9. Citations: 815     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
    10. Pruijssers AJ, George AS, Schäfer A, Leist SR, Gralinksi LE, Dinnon KH, Yount BL, Agostini ML, Stevens LJ, Chappell JD, Lu X, Hughes TM, Gully K, Martinez DR, Brown AJ, Graham RL, Perry JK, Du Pont V, Pitts J, Ma B, Babusis D, Murakami E, Feng JY, Bilello JP, Porter DP, Cihlar T, Baric RS, Denison MR, Sheahan TP. Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice. Cell Rep. 2020 07 21; 32(3):107940. PMID: 32668216.
      Citations: 149     Fields:    
    11. Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schäfer A, Dinnon KH, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, Montgomery SA, Brown AJ, Bluemling GR, Natchus MG, Saindane M, Kolykhalov AA, Painter G, Harcourt J, Tamin A, Thornburg NJ, Swanstrom R, Denison MR, Baric RS. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med. 2020 04 29; 12(541). PMID: 32253226.
      Citations: 271     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    12. Sheahan TP, Sims AC, Leist SR, Schäfer A, Won J, Brown AJ, Montgomery SA, Hogg A, Babusis D, Clarke MO, Spahn JE, Bauer L, Sellers S, Porter D, Feng JY, Cihlar T, Jordan R, Denison MR, Baric RS. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. 2020 01 10; 11(1):222. PMID: 31924756.
      Citations: 630     Fields:    Translation:HumansAnimalsCells
    13. Agostini ML, Pruijssers AJ, Chappell JD, Gribble J, Lu X, Andres EL, Bluemling GR, Lockwood MA, Sheahan TP, Sims AC, Natchus MG, Saindane M, Kolykhalov AA, Painter GR, Baric RS, Denison MR. Small-Molecule Antiviral ß-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance. J Virol. 2019 12 15; 93(24). PMID: 31578288.
      Citations: 57     Fields:    Translation:AnimalsCells
    14. Graepel KW, Agostini ML, Lu X, Sexton NR, Denison MR. Fitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus. J Virol. 2019 10 15; 93(20). PMID: 31341046.
      Citations: 4     Fields:    Translation:Cells
    15. Wang N, Rosen O, Wang L, Turner HL, Stevens LJ, Corbett KS, Bowman CA, Pallesen J, Shi W, Zhang Y, Leung K, Kirchdoerfer RN, Becker MM, Denison MR, Chappell JD, Ward AB, Graham BS, McLellan JS. Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD. Cell Rep. 2019 09 24; 28(13):3395-3405.e6. PMID: 31553909.
      Citations: 30     Fields:    Translation:HumansCells
    16. Brown AJ, Won JJ, Graham RL, Dinnon KH, Sims AC, Feng JY, Cihlar T, Denison MR, Baric RS, Sheahan TP. Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase. Antiviral Res. 2019 09; 169:104541. PMID: 31233808.
      Citations: 159     Fields:    Translation:HumansAnimalsCells
    17. Pruijssers AJ, Denison MR. Nucleoside analogues for the treatment of coronavirus infections. Curr Opin Virol. 2019 04; 35:57-62. PMID: 31125806.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    18. Athmer J, Fehr AR, Grunewald ME, Qu W, Wheeler DL, Graepel KW, Channappanavar R, Sekine A, Aldabeeb DS, Gale M, Denison MR, Perlman S. Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses. mBio. 2018 05 01; 9(3). PMID: 29717007.
      Citations: 9     Fields:    Translation:AnimalsCells
    19. Wang L, Shi W, Chappell JD, Joyce MG, Zhang Y, Kanekiyo M, Becker MM, van Doremalen N, Fischer R, Wang N, Corbett KS, Choe M, Mason RD, Van Galen JG, Zhou T, Saunders KO, Tatti KM, Haynes LM, Kwong PD, Modjarrad K, Kong WP, McLellan JS, Denison MR, Munster VJ, Mascola JR, Graham BS. Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape. J Virol. 2018 05 15; 92(10). PMID: 29514901.
      Citations: 75     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    20. Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. mBio. 2018 03 06; 9(2). PMID: 29511076.
      Citations: 521     Fields:    Translation:AnimalsCells
    21. Case JB, Li Y, Elliott R, Lu X, Graepel KW, Sexton NR, Smith EC, Weiss SR, Denison MR. Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity. J Virol. 2018 01 01; 92(1). PMID: 29046453.
      Citations: 27     Fields:    Translation:AnimalsCells
    22. Graepel KW, Lu X, Case JB, Sexton NR, Smith EC, Denison MR. Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations. mBio. 2017 11 07; 8(6). PMID: 29114026.
      Citations: 21     Fields:    Translation:AnimalsCells
    23. Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS. Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen. Proc Natl Acad Sci U S A. 2017 08 29; 114(35):E7348-E7357. PMID: 28807998.
      Citations: 334     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    24. Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Spahn JE, Palmiotti CA, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med. 2017 06 28; 9(396). PMID: 28659436.
      Citations: 572     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    25. Arabi YM, Balkhy HH, Hayden FG, Bouchama A, Luke T, Baillie JK, Al-Omari A, Hajeer AH, Senga M, Denison MR, Nguyen-Van-Tam JS, Shindo N, Bermingham A, Chappell JD, Van Kerkhove MD, Fowler RA. Middle East Respiratory Syndrome. N Engl J Med. 2017 02 09; 376(6):584-594. PMID: 28177862.
      Citations: 171     Fields:    Translation:HumansAnimalsCells
    26. Athmer J, Fehr AR, Grunewald M, Smith EC, Denison MR, Perlman S. In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins. mBio. 2017 01 31; 8(1). PMID: 28143984.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    27. Case JB, Ashbrook AW, Dermody TS, Denison MR. Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity. J Virol. 2016 08 15; 90(16):7248-7256. PMID: 27252528.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    28. Sexton NR, Smith EC, Blanc H, Vignuzzi M, Peersen OB, Denison MR. Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens. J Virol. 2016 08 15; 90(16):7415-7428. PMID: 27279608.
      Citations: 56     Fields:    Translation:Cells
    29. Wang L, Shi W, Joyce MG, Modjarrad K, Zhang Y, Leung K, Lees CR, Zhou T, Yassine HM, Kanekiyo M, Yang ZY, Chen X, Becker MM, Freeman M, Vogel L, Johnson JC, Olinger G, Todd JP, Bagci U, Solomon J, Mollura DJ, Hensley L, Jahrling P, Denison MR, Rao SS, Subbarao K, Kwong PD, Mascola JR, Kong WP, Graham BS. Evaluation of candidate vaccine approaches for MERS-CoV. Nat Commun. 2015 Jul 28; 6:7712. PMID: 26218507.
      Citations: 138     Fields:    Translation:HumansAnimalsCells
    30. Mainou BA, Ashbrook AW, Smith EC, Dorset DC, Denison MR, Dermody TS. Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry. J Virol. 2015 Sep; 89(17):8701-12. PMID: 26109733.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    31. Tomar S, Johnston ML, St John SE, Osswald HL, Nyalapatla PR, Paul LN, Ghosh AK, Denison MR, Mesecar AD. Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS. J Biol Chem. 2015 Aug 07; 290(32):19403-22. PMID: 26055715.
      Citations: 48     Fields:    Translation:Cells
    32. Smith EC, Case JB, Blanc H, Isakov O, Shomron N, Vignuzzi M, Denison MR. Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity. J Virol. 2015 Jun; 89(12):6418-26. PMID: 25855750.
      Citations: 26     Fields:    Translation:AnimalsCells
    33. Beachboard DC, Anderson-Daniels JM, Denison MR. Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications. J Virol. 2015 Feb; 89(4):2080-9. PMID: 25473044.
      Citations: 20     Fields:    Translation:Cells
    34. Freeman MC, Peek CT, Becker MM, Smith EC, Denison MR. Coronaviruses induce entry-independent, continuous macropinocytosis. mBio. 2014 Aug 05; 5(4):e01340-14. PMID: 25096879.
      Citations: 15     Fields:    Translation:AnimalsCells
    35. Smith EC, Sexton NR, Denison MR. Thinking Outside the Triangle: Replication Fidelity of the Largest RNA Viruses. Annu Rev Virol. 2014 Nov; 1(1):111-32. PMID: 26958717.
      Citations: 47     Fields:    
    36. Agnihothram S, Yount BL, Donaldson EF, Huynh J, Menachery VD, Gralinski LE, Graham RL, Becker MM, Tomar S, Scobey TD, Osswald HL, Whitmore A, Gopal R, Ghosh AK, Mesecar A, Zambon M, Heise M, Denison MR, Baric RS. A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant. mBio. 2014 Mar 25; 5(2):e00047-14. PMID: 24667706.
      Citations: 34     Fields:    Translation:AnimalsCells
    37. Freeman MC, Graham RL, Lu X, Peek CT, Denison MR. Coronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation. J Virol. 2014 May; 88(10):5319-27. PMID: 24623413.
      Citations: 13     Fields:    Translation:AnimalsCells
    38. Smith EC, Denison MR. Coronaviruses as DNA wannabes: a new model for the regulation of RNA virus replication fidelity. PLoS Pathog. 2013; 9(12):e1003760. PMID: 24348241.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    39. Agnihothram S, Gopal R, Yount BL, Donaldson EF, Menachery VD, Graham RL, Scobey TD, Gralinski LE, Denison MR, Zambon M, Baric RS. Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses. J Infect Dis. 2014 Apr 01; 209(7):995-1006. PMID: 24253287.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    40. Stobart CC, Sexton NR, Munjal H, Lu X, Molland KL, Tomar S, Mesecar AD, Denison MR. Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity. J Virol. 2013 Dec; 87(23):12611-8. PMID: 24027335.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    41. Smith EC, Blanc H, Surdel MC, Vignuzzi M, Denison MR. Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics. PLoS Pathog. 2013 Aug; 9(8):e1003565. PMID: 23966862.
      Citations: 165     Fields:    Translation:HumansAnimalsCells
    42. Graham RL, Becker MM, Eckerle LD, Bolles M, Denison MR, Baric RS. A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease. Nat Med. 2012 Dec; 18(12):1820-6. PMID: 23142821.
      Citations: 119     Fields:    Translation:AnimalsCells
    43. Beachboard DC, Lu X, Baker SC, Denison MR. Murine hepatitis virus nsp4 N258T mutants are not temperature-sensitive. Virology. 2013 Jan 20; 435(2):210-3. PMID: 23099203.
      Citations: 4     Fields:    Translation:AnimalsCells
    44. Smith EC, Denison MR. Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses. Curr Opin Virol. 2012 Oct; 2(5):519-24. PMID: 22857992.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    45. Stobart CC, Lee AS, Lu X, Denison MR. Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity. J Virol. 2012 May; 86(9):4801-10. PMID: 22345451.
      Citations: 18     Fields:    Translation:AnimalsCells
    46. Denison MR, Graham RL, Donaldson EF, Eckerle LD, Baric RS. Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity. RNA Biol. 2011 Mar-Apr; 8(2):270-9. PMID: 21593585.
      Citations: 188     Fields:    Translation:HumansAnimalsCells
    47. Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, Denison MR, Choe H, Farzan M. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 2011 Jan 06; 7(1):e1001258. PMID: 21253575.
      Citations: 306     Fields:    Translation:HumansAnimalsCells
    48. Eckerle LD, Becker MM, Halpin RA, Li K, Venter E, Lu X, Scherbakova S, Graham RL, Baric RS, Stockwell TB, Spiro DJ, Denison MR. Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing. PLoS Pathog. 2010 May 06; 6(5):e1000896. PMID: 20463816.
      Citations: 184     Fields:    Translation:AnimalsCells
    49. Gadlage MJ, Denison MR. Exchange of the coronavirus replicase polyprotein cleavage sites alters protease specificity and processing. J Virol. 2010 Jul; 84(13):6894-8. PMID: 20427532.
      Citations: 8     Fields:    Translation:Cells
    50. Gadlage MJ, Sparks JS, Beachboard DC, Cox RG, Doyle JD, Stobart CC, Denison MR. Murine hepatitis virus nonstructural protein 4 regulates virus-induced membrane modifications and replication complex function. J Virol. 2010 Jan; 84(1):280-90. PMID: 19846526.
      Citations: 42     Fields:    Translation:Cells
    51. Becker MM, Graham RL, Donaldson EF, Rockx B, Sims AC, Sheahan T, Pickles RJ, Corti D, Johnston RE, Baric RS, Denison MR. Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19944-9. PMID: 19036930.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    52. Gadlage MJ, Graham RL, Denison MR. Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization. J Virol. 2008 Dec; 82(23):11964-9. PMID: 18815297.
      Citations: 14     Fields:    Translation:AnimalsCells
    53. Sparks JS, Donaldson EF, Lu X, Baric RS, Denison MR. A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing. J Virol. 2008 Jun; 82(12):5999-6008. PMID: 18385240.
      Citations: 10     Fields:    Translation:AnimalsCells
    54. Sparks JS, Lu X, Denison MR. Genetic analysis of Murine hepatitis virus nsp4 in virus replication. J Virol. 2007 Nov; 81(22):12554-63. PMID: 17855548.
      Citations: 22     Fields:    Translation:AnimalsCells
    55. Eckerle LD, Lu X, Sperry SM, Choi L, Denison MR. High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants. J Virol. 2007 Nov; 81(22):12135-44. PMID: 17804504.
      Citations: 142     Fields:    Translation:AnimalsCells
    56. Zhao Z, Thackray LB, Miller BC, Lynn TM, Becker MM, Ward E, Mizushima NN, Denison MR, Virgin HW. Coronavirus replication does not require the autophagy gene ATG5. Autophagy. 2007 Nov-Dec; 3(6):581-5. PMID: 17700057.
      Citations: 115     Fields:    Translation:AnimalsCells
    57. Deming DJ, Graham RL, Denison MR, Baric RS. Processing of open reading frame 1a replicase proteins nsp7 to nsp10 in murine hepatitis virus strain A59 replication. J Virol. 2007 Oct; 81(19):10280-91. PMID: 17634238.
      Citations: 38     Fields:    Translation:AnimalsCells
    58. Donaldson EF, Graham RL, Sims AC, Denison MR, Baric RS. Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processing. J Virol. 2007 Jul; 81(13):7086-98. PMID: 17428870.
      Citations: 32     Fields:    Translation:AnimalsCells
    59. Graham RL, Sparks JS, Eckerle LD, Sims AC, Denison MR. SARS coronavirus replicase proteins in pathogenesis. Virus Res. 2008 Apr; 133(1):88-100. PMID: 17397959.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    60. Donaldson EF, Sims AC, Graham RL, Denison MR, Baric RS. Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis. J Virol. 2007 Jun; 81(12):6356-68. PMID: 17392363.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    61. Graham RL, Denison MR. Replication of murine hepatitis virus is regulated by papain-like proteinase 1 processing of nonstructural proteins 1, 2, and 3. J Virol. 2006 Dec; 80(23):11610-20. PMID: 16971428.
      Citations: 26     Fields:    Translation:AnimalsCells
    62. Eckerle LD, Brockway SM, Sperry SM, Lu X, Denison MR. Effects of mutagenesis of murine hepatitis virus nsp1 and nsp14 on replication in culture. Adv Exp Med Biol. 2006; 581:55-60. PMID: 17037504.
      Citations: 9     Fields:    Translation:AnimalsCells
    63. Graham RL, Sims AC, Baric RS, Denison MR. The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication. Adv Exp Med Biol. 2006; 581:67-72. PMID: 17037506.
      Citations: 13     Fields:    Translation:AnimalsCells
    64. Deming DJ, Graham RL, Denison MR, Baric RS. MHV-A59 ORF1a replicase protein nsp7-nsp10 processing in replication. Adv Exp Med Biol. 2006; 581:101-4. PMID: 17037513.
      Citations: 2     Fields:    Translation:AnimalsCells
    65. Yount B, Roberts RS, Sims AC, Deming D, Frieman MB, Sparks J, Denison MR, Davis N, Baric RS. Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice. J Virol. 2005 Dec; 79(23):14909-22. PMID: 16282490.
      Citations: 145     Fields:    Translation:AnimalsCells
    66. Graham RL, Sims AC, Brockway SM, Baric RS, Denison MR. The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication. J Virol. 2005 Nov; 79(21):13399-411. PMID: 16227261.
      Citations: 91     Fields:    Translation:AnimalsCells
    67. Brockway SM, Denison MR. Mutagenesis of the murine hepatitis virus nsp1-coding region identifies residues important for protein processing, viral RNA synthesis, and viral replication. Virology. 2005 Sep 30; 340(2):209-23. PMID: 16051301.
      Citations: 45     Fields:    Translation:AnimalsCells
    68. Sperry SM, Kazi L, Graham RL, Baric RS, Weiss SR, Denison MR. Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice. J Virol. 2005 Mar; 79(6):3391-400. PMID: 15731233.
      Citations: 56     Fields:    Translation:AnimalsCells
    69. Brockway SM, Lu XT, Peters TR, Dermody TS, Denison MR. Intracellular localization and protein interactions of the gene 1 protein p28 during mouse hepatitis virus replication. J Virol. 2004 Nov; 78(21):11551-62. PMID: 15479796.
      Citations: 31     Fields:    Translation:AnimalsCells
    70. Denison MR. Severe acute respiratory syndrome coronavirus pathogenesis, disease and vaccines: an update. Pediatr Infect Dis J. 2004 Nov; 23(11 Suppl):S207-14. PMID: 15577575.
      Citations: 19     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    71. Prentice E, McAuliffe J, Lu X, Subbarao K, Denison MR. Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins. J Virol. 2004 Sep; 78(18):9977-86. PMID: 15331731.
      Citations: 146     Fields:    Translation:AnimalsCells
    72. Denison MR, Yount B, Brockway SM, Graham RL, Sims AC, Lu X, Baric RS. Cleavage between replicase proteins p28 and p65 of mouse hepatitis virus is not required for virus replication. J Virol. 2004 Jun; 78(11):5957-65. PMID: 15140993.
      Citations: 31     Fields:    Translation:Cells
    73. Prentice E, Jerome WG, Yoshimori T, Mizushima N, Denison MR. Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem. 2004 Mar 12; 279(11):10136-41. PMID: 14699140.
      Citations: 223     Fields:    Translation:AnimalsCells
    74. Yount B, Curtis KM, Fritz EA, Hensley LE, Jahrling PB, Prentice E, Denison MR, Geisbert TW, Baric RS. Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12995-3000. PMID: 14569023.
      Citations: 190     Fields:    Translation:HumansAnimalsCells
    75. Brockway SM, Clay CT, Lu XT, Denison MR. Characterization of the expression, intracellular localization, and replication complex association of the putative mouse hepatitis virus RNA-dependent RNA polymerase. J Virol. 2003 Oct; 77(19):10515-27. PMID: 12970436.
      Citations: 64     Fields:    Translation:AnimalsCells
    76. Yount B, Denison MR, Weiss SR, Baric RS. Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59. J Virol. 2002 Nov; 76(21):11065-78. PMID: 12368349.
      Citations: 178     Fields:    Translation:AnimalsCells
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