Autophagy-Related Protein 5
"Autophagy-Related Protein 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autophagy-related protein that functions in AUTOPHAGOSOME biogenesis. It is conjugated to the ATG12 PROTEIN via a process that is similar to UBIQUITINATION and involves the ATG7 PROTEIN and ATG10 enzyme. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN LIGASE-like enzyme and is required for the localization of ATG8 PROTEINS to AUTOPHAGOSOME vesicle membranes and modification of membrane lipids.
| Descriptor ID |
D000071187
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| MeSH Number(s) |
D12.776.094.250
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| Concept/Terms |
Autophagy-Related Protein 5- Autophagy-Related Protein 5
- Autophagy Related Protein 5
- Apoptosis-Specific Protein
- Apoptosis Specific Protein
- ATG5 Protein
- ATG-5 Protein
- ATG 5 Protein
- Autophagy Protein-5
- Autophagy Protein 5
- Autophagy-Related 5 Protein
- Autophagy Related 5 Protein
|
Below are MeSH descriptors whose meaning is more general than "Autophagy-Related Protein 5".
Below are MeSH descriptors whose meaning is more specific than "Autophagy-Related Protein 5".
This graph shows the total number of publications written about "Autophagy-Related Protein 5" by people in this website by year, and whether "Autophagy-Related Protein 5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 3 | 1 | 4 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Autophagy-Related Protein 5" by people in Profiles.
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Coronavirus interactions with the cellular autophagy machinery. Autophagy. 2020 12; 16(12):2131-2139.
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The ER stress sensor IRE1 and MAP kinase ERK modulate autophagy induction in cells infected with coronavirus infectious bronchitis virus. Virology. 2019 07; 533:34-44.
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miR-34a inhibits progression of neuroblastoma by targeting autophagy-related gene 5. Eur J Pharmacol. 2019 May 05; 850:53-63.
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Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice. Gastroenterology. 2019 01; 156(1):203-217.e20.
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Evaluation of ATG5 polymorphisms in Italian patients with systemic lupus erythematosus: contribution to disease susceptibility and clinical phenotypes. Lupus. 2018 Aug; 27(9):1464-1469.
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Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Hum Mol Genet. 2018 04 15; 27(8):1332-1342.
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Inhibition of autophagy promotes cisplatin-induced apoptotic cell death through Atg5 and Beclin 1 in A549 human lung cancer cells. Mol Med Rep. 2018 05; 17(5):6859-6865.
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Autophagy-induced KDR/VEGFR-2 activation promotes the formation of vasculogenic mimicry by glioma stem cells. Autophagy. 2017 Sep 02; 13(9):1528-1542.
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Alternative autophagy, brefeldin A and viral trafficking pathways. Autophagy. 2016 09; 12(9):1429-30.
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Autophagy Negatively Regulates Transmissible Gastroenteritis Virus Replication. Sci Rep. 2016 Mar 31; 6:23864.