"Sequestosome-1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.
| Descriptor ID |
D000071456
|
| MeSH Number(s) |
D12.644.360.024.329 D12.776.094.750 D12.776.157.057.160 D12.776.476.024.422
|
| Concept/Terms |
Sequestosome-1 Protein- Sequestosome-1 Protein
- Sequestosome 1 Protein
- Ubiquitin-Binding Protein p62
- Ubiquitin Binding Protein p62
- Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda
- Phosphotyrosine Independent Ligand For The Lck SH2 Domain Of 62 Kda
- EBI3-Associated Protein of 60 KDa
- EBI3 Associated Protein of 60 KDa
- EBIAP Protein
|
Below are MeSH descriptors whose meaning is more general than "Sequestosome-1 Protein".
Below are MeSH descriptors whose meaning is more specific than "Sequestosome-1 Protein".
This graph shows the total number of publications written about "Sequestosome-1 Protein" by people in this website by year, and whether "Sequestosome-1 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 4 | 5 |
| 2018 | 0 | 2 | 2 |
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Below are the most recent publications written about "Sequestosome-1 Protein" by people in Profiles.
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Physostigmine Restores Impaired Autophagy in the Rat Hippocampus after Surgery Stress and LPS Treatment. J Neuroimmune Pharmacol. 2018 09; 13(3):383-395.
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Panduratin A induces protective autophagy in melanoma via the AMPK and mTOR pathway. Phytomedicine. 2018 Mar 15; 42:144-151.
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Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation. Redox Biol. 2018 04; 14:609-617.
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Upregulation of connexin43 by glucose deprivation in H9c2 cells via the extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway. Mol Med Rep. 2018 Jan; 17(1):729-734.
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DNAJC12 and dopa-responsive nonprogressive parkinsonism. Ann Neurol. 2017 Oct; 82(4):640-646.
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w09, a novel autophagy enhancer, induces autophagy-dependent cell apoptosis via activation of the EGFR-mediated RAS-RAF1-MAP2K-MAPK1/3 pathway. Autophagy. 2017 Jul 03; 13(7):1093-1112.
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p62-Mediated mitochondrial clustering attenuates apoptosis induced by mitochondrial depolarization. Biochim Biophys Acta Mol Cell Res. 2017 Jul; 1864(7):1308-1317.
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FK506, an Immunosuppressive Drug, Induces Autophagy by Binding to the V-ATPase Catalytic Subunit A in Neuronal Cells. J Proteome Res. 2017 01 06; 16(1):55-64.