"Endoribonucleases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of enzymes that catalyze the endonucleolytic cleavage of RNA. It includes EC 3.1.26.-, EC 3.1.27.-, EC 3.1.30.-, and EC 3.1.31.-.
| Descriptor ID |
D004722
|
| MeSH Number(s) |
D08.811.277.352.355.350 D08.811.277.352.700.350
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Endoribonucleases".
Below are MeSH descriptors whose meaning is more specific than "Endoribonucleases".
This graph shows the total number of publications written about "Endoribonucleases" by people in this website by year, and whether "Endoribonucleases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2006 | 4 | 1 | 5 |
| 2009 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
| 2016 | 5 | 0 | 5 |
| 2017 | 7 | 0 | 7 |
| 2018 | 4 | 0 | 4 |
| 2019 | 0 | 2 | 2 |
| 2020 | 4 | 3 | 7 |
| 2021 | 3 | 1 | 4 |
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Below are the most recent publications written about "Endoribonucleases" by people in Profiles.
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Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses. Virulence. 2021 12; 12(1):444-469.
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Efficient Inhibition of SARS-CoV-2 Using Chimeric Antisense Oligonucleotides through RNase L Activation*. Angew Chem Int Ed Engl. 2021 09 27; 60(40):21662-21667.
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SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block. RNA. 2021 11; 27(11):1318-1329.
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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease. Biochem J. 2021 07 16; 478(13):2465-2479.
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Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection. PLoS Pathog. 2021 06; 17(6):e1009644.
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Epigallocatechin Gallate Inhibits the Uridylate-Specific Endoribonuclease Nsp15 and Efficiently Neutralizes the SARS-CoV-2 Strain. J Agric Food Chem. 2021 Jun 02; 69(21):5948-5954.
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Analysis of natural compounds against the activity of SARS-CoV-2 NSP15 protein towards an effective treatment against COVID-19: a theoretical and computational biology approach. J Mol Model. 2021 May 08; 27(6):160.
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High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity. PLoS One. 2021; 16(4):e0250019.
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Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease. J Med Chem. 2021 05 13; 64(9):5632-5644.
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SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes. Proc Natl Acad Sci U S A. 2021 04 20; 118(16).