Poly(ADP-ribose) Polymerases
"Poly(ADP-ribose) Polymerases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.
| Descriptor ID |
D011065
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| MeSH Number(s) |
D08.811.913.400.725.115.690
|
| Concept/Terms |
Poly(ADP-ribose) Polymerases- Poly(ADP-ribose) Polymerases
- ADP-Ribosyltransferase (Polymerizing)
- Poly(ADP-ribose) Polymerase
- Poly ADP Ribose Polymerase
- Poly ADP Ribose Transferase
- Poly(ADP-Ribose) Transferase
- PARP Polymerase
- Polymerase, PARP
- Poly(ADPribose) Polymerase
- Poly ADP-Ribose Synthase
- Poly ADP Ribose Synthase
- Synthase, Poly ADP-Ribose
- Poly(ADPR) Polymerase
- Poly(ADP-Ribose) Synthase
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Below are MeSH descriptors whose meaning is more general than "Poly(ADP-ribose) Polymerases".
Below are MeSH descriptors whose meaning is more specific than "Poly(ADP-ribose) Polymerases".
This graph shows the total number of publications written about "Poly(ADP-ribose) Polymerases" by people in this website by year, and whether "Poly(ADP-ribose) Polymerases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2017 | 0 | 3 | 3 |
| 2018 | 0 | 5 | 5 |
| 2019 | 2 | 0 | 2 |
| 2020 | 2 | 0 | 2 |
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Below are the most recent publications written about "Poly(ADP-ribose) Polymerases" by people in Profiles.
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Host ADP-ribosylation and the SARS-CoV-2 macrodomain. Biochem Soc Trans. 2021 08 27; 49(4):1711-1721.
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The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling. J Biol Chem. 2021 09; 297(3):101041.
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Can molecular mimicry explain the cytokine storm of SARS-CoV-2?: An in silico approach. J Med Virol. 2021 Sep; 93(9):5350-5357.
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The potential association between PARP14 and SARS-CoV-2 infection (COVID-19). Future Med Chem. 2021 03; 13(6):587-592.
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Stenoparib, an Inhibitor of Cellular Poly(ADP-Ribose) Polymerase, Blocks Replication of the SARS-CoV-2 and HCoV-NL63 Human Coronaviruses In Vitro. mBio. 2021 01 19; 12(1).
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ADP-ribosylhydrolases: from DNA damage repair to COVID-19. J Zhejiang Univ Sci B. 2021 Jan 15; 22(1):21-30.
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Role of Poly(ADP-ribose) Polymerase (PARP1) in Viral Infection and its Implication in SARS-CoV-2 Pathogenesis. Curr Drug Targets. 2021; 22(13):1477-1484.
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Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential. Open Biol. 2020 11; 10(11):200237.
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Saporin, a Polynucleotide-Adenosine Nucleosidase, May Be an Efficacious Therapeutic Agent for SARS-CoV-2 Infection. SLAS Discov. 2021 03; 26(3):330-335.
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Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity. J Biol Chem. 2020 12 25; 295(52):17986-17996.