"Proinsulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
| Descriptor ID |
D011384
|
| MeSH Number(s) |
D06.472.699.587.200.500 D12.644.548.586.200.500 D12.776.811.706
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Proinsulin".
Below are MeSH descriptors whose meaning is more specific than "Proinsulin".
This graph shows the total number of publications written about "Proinsulin" by people in this website by year, and whether "Proinsulin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2017 | 1 | 2 | 3 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proinsulin" by people in Profiles.
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Biogenesis of the Insulin Secretory Granule in Health and Disease. Adv Exp Med Biol. 2019; 1134:17-32.
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A novel LIPS assay for insulin autoantibodies. Acta Diabetol. 2018 Mar; 55(3):263-270.
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Time-Resolved Fluorescence Assays for Quantification of Insulin Precursors in Plasma and Serum. Methods Mol Biol. 2018; 1735:457-465.
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Non-alcoholic fatty liver disease and impaired proinsulin conversion as newly identified predictors of the long-term non-response to a lifestyle intervention for diabetes prevention: results from the TULIP study. Diabetologia. 2017 12; 60(12):2341-2351.
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Designing structural-motifs for the preparation of acylated proinsulin and their regiospecific conversion into insulin modified at Lys29 (K29). Bioorg Chem. 2017 08; 73:147-153.
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Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice. Am J Hum Genet. 2017 02 02; 100(2):238-256.
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DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11683-8.
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Leptin and adipose tissue maldistribution in HIV-infected male patients with predominant fat loss treated with antiretroviral therapy. J Acquir Immune Defic Syndr. 2002 Jan 01; 29(1):32-40.