"Uncoupling Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.
Descriptor ID |
D014475
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MeSH Number(s) |
D27.505.519.389.936
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Uncoupling Agents".
Below are MeSH descriptors whose meaning is more specific than "Uncoupling Agents".
This graph shows the total number of publications written about "Uncoupling Agents" by people in this website by year, and whether "Uncoupling Agents" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2003 | 0 | 1 | 1 |
2017 | 1 | 1 | 2 |
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Below are the most recent publications written about "Uncoupling Agents" by people in Profiles.
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The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury. Nat Commun. 2017 12 12; 8(1):2068.
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Low concentration of uncouplers of oxidative phosphorylation decreases the TNF-induced endothelial permeability and lethality in mice. Biochim Biophys Acta Mol Basis Dis. 2017 04; 1863(4):968-977.
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Cellular remodeling in heart failure disrupts K(ATP) channel-dependent stress tolerance. EMBO J. 2003 Apr 15; 22(8):1732-42.