Directed Molecular Evolution
"Directed Molecular Evolution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The techniques used to produce molecules exhibiting properties that conform to the demands of the experimenter. These techniques combine methods of generating structural changes with methods of selection. They are also used to examine proposed mechanisms of evolution under in vitro selection conditions.
| Descriptor ID |
D019020
|
| MeSH Number(s) |
E05.393.420.175
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| Concept/Terms |
Directed Molecular Evolution- Directed Molecular Evolution
- Directed Molecular Evolutions
- Evolution, Directed Molecular
- Evolutions, Directed Molecular
- Molecular Evolutions, Directed
- Molecular Evolution, Directed
- Evolution, Molecular, Directed
In Vitro Molecular Evolution- In Vitro Molecular Evolution
- Laboratory Molecular Evolution
- Evolution, Laboratory Molecular
- Evolutions, Laboratory Molecular
- Laboratory Molecular Evolutions
- Molecular Evolution, Laboratory
- Molecular Evolutions, Laboratory
|
Below are MeSH descriptors whose meaning is more general than "Directed Molecular Evolution".
Below are MeSH descriptors whose meaning is more specific than "Directed Molecular Evolution".
This graph shows the total number of publications written about "Directed Molecular Evolution" by people in this website by year, and whether "Directed Molecular Evolution" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 2 | 4 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Directed Molecular Evolution" by people in Profiles.
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Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody. Science. 2021 02 19; 371(6531):823-829.
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De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2. Science. 2020 12 04; 370(6521):1208-1214.
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Design of an engineered ACE2 as a novel therapeutics against COVID-19. J Theor Biol. 2020 11 21; 505:110425.
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Evolution of Chikungunya virus in mosquito cells. Sci Rep. 2018 11 01; 8(1):16175.
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'?Test-tube' evolution wins Chemistry Nobel Prize. Nature. 2018 10; 562(7726):176.
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Incompatible Translation Drives a Convergent Evolution and Viral Attenuation During the Development of Live Attenuated Vaccine. Front Cell Infect Microbiol. 2018; 8:249.
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A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus. PLoS Biol. 2018 06; 16(6):e2006459.
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Gene drives thwarted by emergence of resistant organisms. Nature. 2017 01 31; 542(7639):15.
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Creation of a cardiotropic adeno-associated virus: the story of viral directed evolution. Virol J. 2013 Feb 11; 10:50.
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Rapid discovery and optimization of therapeutic antibodies against emerging infectious diseases. Protein Eng Des Sel. 2008 Aug; 21(8):495-505.