"Protein Engineering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
Descriptor ID |
D015202
|
MeSH Number(s) |
E05.393.420.601
|
Concept/Terms |
Protein Engineering- Protein Engineering
- Engineering, Protein
- Genetic Engineering, Protein
- Engineering, Protein Genetic
- Protein Genetic Engineering
- Proteins, Genetic Engineering
- Genetic Engineering of Proteins
|
Below are MeSH descriptors whose meaning is more general than "Protein Engineering".
Below are MeSH descriptors whose meaning is more specific than "Protein Engineering".
This graph shows the total number of publications written about "Protein Engineering" by people in this website by year, and whether "Protein Engineering" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2003 | 0 | 1 | 1 |
2004 | 1 | 0 | 1 |
2007 | 1 | 0 | 1 |
2009 | 0 | 1 | 1 |
2010 | 1 | 0 | 1 |
2011 | 1 | 0 | 1 |
2012 | 1 | 0 | 1 |
2013 | 2 | 2 | 4 |
2016 | 0 | 1 | 1 |
2017 | 5 | 15 | 20 |
2018 | 8 | 13 | 21 |
2019 | 5 | 2 | 7 |
2020 | 0 | 4 | 4 |
2021 | 3 | 9 | 12 |
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Below are the most recent publications written about "Protein Engineering" by people in Profiles.
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Plant-Produced Glycosylated and In Vivo Deglycosylated Receptor Binding Domain Proteins of SARS-CoV-2 Induce Potent Neutralizing Responses in Mice. Viruses. 2021 08 12; 13(8).
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Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations. J Mol Biol. 2021 09 17; 433(19):167177.
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Protein Engineering in the Design of Protein-Protein Interactions: SARS-CoV-2 Inhibitors as a Test Case. Biochemistry. 2021 11 23; 60(46):3429-3435.
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Rapid generation of potent antibodies by autonomous hypermutation in yeast. Nat Chem Biol. 2021 10; 17(10):1057-1064.
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Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2. Nat Commun. 2021 06 21; 12(1):3802.
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Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers. Nat Commun. 2021 06 16; 12(1):3661.
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Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants. Nature. 2021 07; 595(7869):718-723.
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Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization. Commun Biol. 2021 05 19; 4(1):597.
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A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection. Sci Rep. 2021 05 19; 11(1):10617.
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Coiled-coil heterodimers with increased stability for cellular regulation and sensing SARS-CoV-2 spike protein-mediated cell fusion. Sci Rep. 2021 04 28; 11(1):9136.