Complementarity Determining Regions
"Complementarity Determining Regions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).
Descriptor ID |
D022801
|
MeSH Number(s) |
D12.644.541.500.650.500.180 D12.776.124.486.485.680.650.500.180 D12.776.124.486.485.797.180 D12.776.124.790.651.680.650.500.180 D12.776.124.790.651.797.180 D12.776.377.715.548.680.650.500.180 D12.776.377.715.548.797.180 D12.776.543.750.705.816.824.300 G02.111.570.060.425.160
|
Concept/Terms |
Complementarity Determining Regions- Complementarity Determining Regions
- Region, Complementarity Determining
- Regions, Complementarity Determining
- Hypervariable Regions, Immunoglobulin
- Hypervariable Region, Immunoglobulin
- Immunoglobulin Hypervariable Region
- Immunoglobulin Hypervariable Regions
- Region, Immunoglobulin Hypervariable
- Regions, Immunoglobulin Hypervariable
- Complementarity Determining Region
- Complementarity-Determining Region
- Complementarity-Determining Regions
- Regions, Complementarity-Determining
Complementarity Determining Region 3- Complementarity Determining Region 3
- Complementarity-Determining Region 3
- Complementarity-Determining Region 3s
- Third Complementarity-Determining Region
- Complementarity-Determining Region, Third
- Complementarity-Determining Regions, Third
- Third Complementarity Determining Region
- Third Complementarity-Determining Regions
- Complementarity Determining Region III
|
Below are MeSH descriptors whose meaning is more general than "Complementarity Determining Regions".
Below are MeSH descriptors whose meaning is more specific than "Complementarity Determining Regions".
This graph shows the total number of publications written about "Complementarity Determining Regions" by people in this website by year, and whether "Complementarity Determining Regions" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
2001 | 1 | 0 | 1 |
2008 | 0 | 1 | 1 |
2009 | 1 | 0 | 1 |
2016 | 1 | 0 | 1 |
2017 | 2 | 6 | 8 |
2018 | 1 | 1 | 2 |
2019 | 4 | 1 | 5 |
2020 | 1 | 2 | 3 |
2021 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Complementarity Determining Regions" by people in Profiles.
-
GIANA allows computationally-efficient TCR clustering and multi-disease repertoire classification by isometric transformation. Nat Commun. 2021 08 04; 12(1):4699.
-
Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis. Cell Chem Biol. 2021 09 16; 28(9):1379-1388.e7.
-
Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain. Nat Commun. 2021 06 21; 12(1):3815.
-
HLA class I-associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children. J Clin Invest. 2021 05 17; 131(10).
-
TRB sequences targeting ORF1a/b are associated with disease severity in hospitalized COVID-19 patients. J Leukoc Biol. 2022 01; 111(1):283-289.
-
Use of machine learning to identify a TÂ cell response to SARS-CoV-2. Cell Rep Med. 2021 02 16; 2(2):100192.
-
Major rise of a chronic lymphoid leukemia clone during the course of COVID-19. Int J Lab Hematol. 2021 04; 43(2):e82-e83.
-
An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain. Cell Rep. 2020 10 20; 33(3):108274.
-
Structural basis of a shared antibody response to SARS-CoV-2. Science. 2020 08 28; 369(6507):1119-1123.
-
A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1. J Virol. 2019 11 15; 93(22).