"Mercaptopurine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
| Descriptor ID |
D015122
|
| MeSH Number(s) |
D02.886.489.534 D03.633.100.759.534
|
| Concept/Terms |
Mercaptopurine- Mercaptopurine
- 6-Thiopurine
- 6 Thiopurine
- 6-Mercaptopurine Monohydrate
- 6 Mercaptopurine Monohydrate
- 1,7-Dihydro-6H-purine-6-thione
- 6-Thiohypoxanthine
- 6 Thiohypoxanthine
|
Below are MeSH descriptors whose meaning is more general than "Mercaptopurine".
Below are MeSH descriptors whose meaning is more specific than "Mercaptopurine".
This graph shows the total number of publications written about "Mercaptopurine" by people in this website by year, and whether "Mercaptopurine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 4 | 3 | 7 |
| 2018 | 4 | 2 | 6 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Mercaptopurine" by people in Profiles.
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Effect of IBD medications on COVID-19 outcomes: results from an international registry. Gut. 2021 04; 70(4):725-732.
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Repeat-positive SARS-CoV-2 in a child with cancer. Pediatr Blood Cancer. 2021 03; 68(3):e28744.
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SARS-CoV-2 infection in a 7-year-old girl with pancytopenia during acute lymphocytic leukemia maintenance therapy. Pediatr Blood Cancer. 2020 11; 67(11):e28391.
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Impact of Anti-Tumor Necrosis Factor and Thiopurine Medications on the Development of COVID-19 in Patients With Inflammatory Bowel Disease: A Nationwide Veterans Administration Cohort Study. Gastroenterology. 2020 10; 159(4):1545-1546.e1.
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COVID-19 and implications for thiopurine use. Med J Aust. 2020 06; 212(10):490-490.e1.
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Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study. J Clin Oncol. 2019 09 01; 37(25):2246-2256.
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Pharmacokinetics and Immune Reconstitution Following Discontinuation of Thiopurine Analogues: Implications for Drug Withdrawal Strategies. J Crohns Colitis. 2018 Nov 28; 12(12):1410-1417.
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Higher Thioguanine Nucleotide Metabolite Levels are Associated With Better Long-term Outcomes in Patients With Inflammatory Bowel Diseases. J Clin Gastroenterol. 2018 07; 52(6):537-544.
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Acute Lymphoblastic Leukemia with Hypereosinophilia in a Child: Case Report and Literature Review. Int J Environ Res Public Health. 2018 06 04; 15(6).
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Thiopurines in Inflammatory Bowel Disease: New Findings and Perspectives. J Crohns Colitis. 2018 Apr 27; 12(5):610-620.