"Leucine Zippers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.
| Descriptor ID |
D016350
|
| MeSH Number(s) |
G02.111.570.820.709.275.500.520
|
| Concept/Terms |
Leucine Zippers- Leucine Zippers
- Leucine Zipper
- Zipper, Leucine
- Zippers, Leucine
|
Below are MeSH descriptors whose meaning is more general than "Leucine Zippers".
Below are MeSH descriptors whose meaning is more specific than "Leucine Zippers".
This graph shows the total number of publications written about "Leucine Zippers" by people in this website by year, and whether "Leucine Zippers" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "Leucine Zippers" by people in Profiles.
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Increased Glucocorticoid Receptor Alpha Expression and Signaling in Critically Ill Coronavirus Disease 2019 Patients. Crit Care Med. 2021 12 01; 49(12):2131-2136.
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Glucocorticoid-Glucocorticoid Receptor Response to Severe Acute Respiratory Syndrome Coronavirus 2. Crit Care Med. 2021 12 01; 49(12):2157-2160.
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Role of GILZ in the Kidney and the Cardiovascular System: Relevance to Cardiorenal Complications of COVID-19. J Pharmacol Exp Ther. 2020 12; 375(3):398-405.
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A stage-specific functional role of the leucine zipper transcription factor c-Maf in lung Th2 cell differentiation. Eur J Immunol. 2004 Dec; 34(12):3401-12.
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Amino acid substitutions within the leucine zipper domain of the murine coronavirus spike protein cause defects in oligomerization and the ability to induce cell-to-cell fusion. J Virol. 1999 Oct; 73(10):8152-9.
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A leucine zipper structure present in the measles virus fusion protein is not required for its tetramerization but is essential for fusion. J Gen Virol. 1992 Jul; 73 ( Pt 7):1703-7.
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Coronavirus motif. Nature. 1991 Oct 03; 353(6343):394.