"Neurofilament Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)
| Descriptor ID |
D016900
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| MeSH Number(s) |
D05.750.078.593.630 D12.776.220.475.630 D12.776.631.630
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Neurofilament Proteins".
Below are MeSH descriptors whose meaning is more specific than "Neurofilament Proteins".
This graph shows the total number of publications written about "Neurofilament Proteins" by people in this website by year, and whether "Neurofilament Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2017 | 4 | 3 | 7 |
| 2018 | 4 | 4 | 8 |
| 2019 | 2 | 1 | 3 |
| 2020 | 2 | 2 | 4 |
| 2021 | 3 | 6 | 9 |
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Below are the most recent publications written about "Neurofilament Proteins" by people in Profiles.
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Neurological symptoms and axonal damage in COVID-19 survivors: are there sequelae? Immunol Res. 2021 12; 69(6):553-557.
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Neurochemical signs of astrocytic and neuronal injury in acute COVID-19 normalizes during long-term follow-up. EBioMedicine. 2021 Aug; 70:103512.
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Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19. Sci Transl Med. 2021 07 14; 13(602).
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Neurofilament Light Chain in Patients with COVID-19 and Bacterial Pneumonia. Ann Neurol. 2021 07; 90(1):174-175.
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Reply to: Neurofilament Light Chain in Patients with COVID-19 and Bacterial Pneumonia. Ann Neurol. 2021 07; 90(1):175-176.
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Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients. J Neurol. 2021 Dec; 268(12):4436-4442.
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Serum neurofilament light chain (sNfL) values in a large cross-sectional population of children with asymptomatic to moderate COVID-19. J Neurol. 2021 Nov; 268(11):3969-3974.
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Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19. J Neurol. 2021 Oct; 268(10):3574-3583.
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Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations. Cells. 2021 02 13; 10(2).
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Biomarkers for central nervous system injury in cerebrospinal fluid are elevated in COVID-19 and associated with neurological symptoms and disease severity. Eur J Neurol. 2021 10; 28(10):3324-3331.