"Ataxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of predominantly nuclear proteins that regulate gene transcription and protein degradation. The expansion of CAG trinucleotide repeats in genes that encode Ataxins is associated with SPINOCEREBELLAR ATAXIAS (SCA). In SCA patients, the number of CAG repeats correlates with the severity of disease and inversely correlates with the age of disease onset.
| Descriptor ID |
D000067528
|
| MeSH Number(s) |
D12.776.631.069 D12.776.660.075
|
| Concept/Terms |
Ataxins- Ataxins
- Spinocerebellar Ataxia Proteins
- Ataxia Proteins, Spinocerebellar
- Proteins, Spinocerebellar Ataxia
- Ataxin Proteins
- Proteins, Ataxin
|
Below are MeSH descriptors whose meaning is more general than "Ataxins".
Below are MeSH descriptors whose meaning is more specific than "Ataxins".
This graph shows the total number of publications written about "Ataxins" by people in this website by year, and whether "Ataxins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ataxins" by people in Profiles.
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Docosahexaenoic acid is a beneficial replacement treatment for spinocerebellar ataxia 38. Ann Neurol. 2017 Oct; 82(4):615-621.
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Variegation of the phenotype induced by the Gata1low mutation in mice of different genetic backgrounds. Blood. 2005 Dec 15; 106(13):4102-13.