"Protein Phosphatase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A eukayrotic protein serine-threonine phosphatase subtype that dephosphorylates a wide variety of cellular proteins. The enzyme is comprised of a catalytic subunit and regulatory subunit. Several isoforms of the protein phosphatase catalytic subunit exist due to the presence of multiple genes and the alternative splicing of their mRNAs. A large number of proteins have been shown to act as regulatory subunits for this enzyme. Many of the regulatory subunits have additional cellular functions.
| Descriptor ID |
D054645
|
| MeSH Number(s) |
D08.811.277.352.650.625.687
|
| Concept/Terms |
Protein Phosphatase 1- Protein Phosphatase 1
- Protein Phosphatase-1
- Type 1 Serine Threonine Protein Phosphatase
- PP1c Enzyme
|
Below are MeSH descriptors whose meaning is more general than "Protein Phosphatase 1".
Below are MeSH descriptors whose meaning is more specific than "Protein Phosphatase 1".
This graph shows the total number of publications written about "Protein Phosphatase 1" by people in this website by year, and whether "Protein Phosphatase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2017 | 1 | 2 | 3 |
| 2018 | 2 | 0 | 2 |
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Below are the most recent publications written about "Protein Phosphatase 1" by people in Profiles.
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Homoharringtonine regulates the alternative splicing of Bcl-x and caspase 9 through a protein phosphatase 1-dependent mechanism. BMC Complement Altern Med. 2018 May 22; 18(1):164.
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Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2a dephosphorylation by the GADD34/PP1c complex. Sci Signal. 2018 01 23; 11(514).
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Activation of the Integrated Stress Response and Metabolic Dysfunction in a Murine Model of Sleep Apnea. Am J Respir Cell Mol Biol. 2017 10; 57(4):477-486.
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PAI1: a novel PP1-interacting protein that mediates human plasma's anti-apoptotic effect in endothelial cells. J Cell Mol Med. 2017 09; 21(9):2068-2076.
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Integrated stress response activation by sleep fragmentation during late gestation in mice leads to emergence of adverse metabolic phenotype in offspring. Metabolism. 2017 04; 69:188-198.
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A human coronavirus OC43 variant harboring persistence-associated mutations in the S glycoprotein differentially induces the unfolded protein response in human neurons as compared to wild-type virus. Virology. 2009 Dec 20; 395(2):255-67.
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Inhibition of protein kinase R activation and upregulation of GADD34 expression play a synergistic role in facilitating coronavirus replication by maintaining de novo protein synthesis in virus-infected cells. J Virol. 2009 Dec; 83(23):12462-72.
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Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am J Respir Crit Care Med. 2005 Sep 15; 172(6):704-12.