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Protein Phosphatase 2

"Protein Phosphatase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.

Descriptor ID	D054648
MeSH Number(s)	D08.811.277.352.650.625.706 D12.644.360.583 D12.776.476.561
Concept/Terms	Protein Phosphatase 2 Protein Phosphatase 2 Protein Phosphatase-2A Protein Phosphatase 2A Protein Phosphatase 2, Catalytic Subunit, alpha Isoform Protein Phosphatase 2, Catalytic Subunit, alpha Isoform PPP2CA Phosphatase Phosphatase, PPP2CA Protein Phosphatase 2A, Catalytic Subunit, alpha Isoform Serine-Threonine-Protein Phosphatase 2A Catalytic Subunit alpha Isoform Serine Threonine Protein Phosphatase 2A Catalytic Subunit alpha Isoform Protein Phosphatase 2, Catalytic Subunit, beta Isoform Protein Phosphatase 2, Catalytic Subunit, beta Isoform Protein Phosphatase 2A, Catalytic Subunit, beta Isoform PPP2CB Phosphatase Phosphatase, PPP2CB Serine Threonine Protein Phosphatase 2A Catalytic Subunit beta Isoform Protein Phosphatase 2, Regulatory Subunit Protein Phosphatase 2, Regulatory Subunit Protein Phosphatase 2, Regulatory Subunit A, alpha Isoform Protein Phosphatase 2, Regulatory Subunit A, alpha Isoform Protein Phosphatase 2A, Regulatory Subunit A , alpha Isoform Protein Phosphatase 2, Regulatory Subunit B, alpha Isoform Protein Phosphatase 2, Regulatory Subunit B, alpha Isoform Protein Phosphatase 2A, Regulatory Subunit B, alpha Isoform Protein Phosphatase 2, Regulatory Subunit B, beta Isoform Protein Phosphatase 2, Regulatory Subunit B, beta Isoform Protein Phosphatase 2A, Regulatory Subunit B, beta Isoform Protein Phosphatase 2, Regulatory Subunit B, delta Isoform Protein Phosphatase 2, Regulatory Subunit B, delta Isoform Protein Phosphatase 2A, Regulatory Subunit B, delta Isoform Protein Phosphatase 2, Regulatory Subunit B, gamma Isoform Protein Phosphatase 2, Regulatory Subunit B, gamma Isoform Protein Phosphatase 2A, Regulatory Subunit B, gamma Isoform Protein Phosphatase 2, Catalytic Subunit Protein Phosphatase 2, Catalytic Subunit Protein Phosphatase 2, Regulatory Subunit A, beta Isoform Protein Phosphatase 2, Regulatory Subunit A, beta Isoform Protein Phosphatase 2A, Regulatory Subunit A, beta Isoform

Below are MeSH descriptors whose meaning is more general than "Protein Phosphatase 2".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Monoester Hydrolases [D08.811.277.352.650]
Phosphoprotein Phosphatases [D08.811.277.352.650.625]
Protein Phosphatase 2 [D08.811.277.352.650.625.706]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Protein Phosphatase 2 [D12.644.360.583]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Protein Phosphatase 2 [D12.776.476.561]

Below are MeSH descriptors whose meaning is related to "Protein Phosphatase 2".

Below are MeSH descriptors whose meaning is more specific than "Protein Phosphatase 2".

Publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Phosphatase 2" by people in this website by year, and whether "Protein Phosphatase 2" was a major or minor topic of these publications.

Bar chart showing 9 publications over 2 distinct years, with a maximum of 5 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2017	3	1	4
2018	3	2	5

Below are the most recent publications written about "Protein Phosphatase 2" by people in Profiles.

MHC Phosphopeptides: Promising Targets for Immunotherapy of Cancer and Other Chronic Diseases. Mol Cell Proteomics. 2021; 20:100112.

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AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis. Dev Cell. 2018 12 03; 47(5):592-607.e6.

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Deletion of Pr72 causes cardiac developmental defects in Zebrafish. PLoS One. 2018; 13(11):e0206883.

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Molecular mechanisms of carfilzomib-induced cardiotoxicity in mice and the emerging cardioprotective role of metformin. Blood. 2019 02 14; 133(7):710-723.

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ER stress regulating protein phosphatase 2A-B56?, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes. Cell Death Dis. 2018 07 09; 9(7):762.

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Cracking novel shared targets between epilepsy and Alzheimer's disease: need of the hour. Rev Neurosci. 2018 Jun 27; 29(4):425-442.

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Musculin inhibits human T-helper 17 cell response to interleukin 2 by controlling STAT5B activity. Eur J Immunol. 2017 09; 47(9):1427-1442.

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T-type Ca2+ channels elicit pro-proliferative and anti-apoptotic responses through impaired PP2A/Akt1 signaling in PASMCs from patients with pulmonary arterial hypertension. Biochim Biophys Acta Mol Cell Res. 2017 Oct; 1864(10):1631-1641.

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Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth. J Clin Invest. 2017 Jun 01; 127(6):2081-2090.

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Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56. EMBO Rep. 2017 03; 18(3):437-450.

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Protein Phosphatase 2