"Calcineurin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
| Descriptor ID |
D019703
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| MeSH Number(s) |
D08.811.277.352.650.625.150 D12.644.360.087 D12.776.476.087
|
| Concept/Terms |
Calcineurin- Calcineurin
- Protein Phosphatase 3
- Phosphatase 3, Protein
- Protein Phosphatase-2B
- Protein Phosphatase 2B
Calcineurin B- Calcineurin B
- Protein Phosphatase 3 Regulatory Subunit
Calcineurin A- Calcineurin A
- Protein Phosphatase 3 Catalytic Subunit
|
Below are MeSH descriptors whose meaning is more general than "Calcineurin".
Below are MeSH descriptors whose meaning is more specific than "Calcineurin".
This graph shows the total number of publications written about "Calcineurin" by people in this website by year, and whether "Calcineurin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2017 | 1 | 4 | 5 |
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Below are the most recent publications written about "Calcineurin" by people in Profiles.
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Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface. Proc Natl Acad Sci U S A. 2020 07 21; 117(29):17195-17203.
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Cyclosporine as a preferred calcineurin inhibitor in renal allograft recipients with COVID-19 infection. Kidney Int. 2020 08; 98(2):507-508.
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Growth hormone-releasing hormone attenuates cardiac hypertrophy and improves heart function in pressure overload-induced heart failure. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):12033-12038.
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Inhibition of Calcineurin or IMP Dehydrogenase Exerts Moderate to Potent Antiviral Activity against Norovirus Replication. Antimicrob Agents Chemother. 2017 11; 61(11).
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Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity. Elife. 2017 10 02; 6.
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Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Facilitates the Development of Cardiac Hypertrophy. Cell Physiol Biochem. 2017; 42(4):1645-1656.
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Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall Remodeling. Antimicrob Agents Chemother. 2017 05; 61(5).
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MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress. Circ Res. 2013 Apr 26; 112(9):1234-43.