Leike Zhang

InstitutionWuhan institute of Virology
AddressWuhan
Hubei
China
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 32 Covid-19 publications, with a maximum of 3 publications in April 2020 and April 2021 and May 2021 and June 2021 and August 2021
    All Publications
    Bar chart showing 49 publications over 10 distinct years, with a maximum of 17 publications in 2021
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

    To see the data from both graphs as text, click here.
    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
    Sort By:     Newest   |   Oldest   |   Most Cited   |   Most Discussed
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang Q, Wang L, Zhang Y, Zhang X, Zhang L, Shang W, Bai F. Probing the Allosteric Inhibition Mechanism of a Spike Protein Using Molecular Dynamics Simulations and Active Compound Identifications. J Med Chem. 2022 02 24; 65(4):2827-2835. PMID: 34415156.
      Citations:    Fields:    
    2. Wang Y, Zhu X, Jiang XM, Guo J, Fu Z, Zhou Z, Yang P, Guo H, Guo X, Liang G, Zeng P, Xiao G, Ma J, Yin X, Zhang LK, Yan C, Zhang CY. Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients. Signal Transduct Target Ther. 2021 08 11; 6(1):300. PMID: 34381015.
      Citations: 1     Translation:HumansCells
    3. Wang L, Wu Y, Yao S, Ge H, Zhu Y, Chen K, Chen WZ, Zhang Y, Zhu W, Wang HY, Guo Y, Ma PX, Ren PX, Zhang XL, Li HQ, Ali MA, Xu WQ, Jiang HL, Zhang LK, Zhu LL, Ye Y, Shang WJ, Bai F. Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein. Acta Pharmacol Sin. 2021 Aug 04. PMID: 34349236.
      Citations: 1     Fields:    
    4. Wang Y, Fang S, Wu Y, Cheng X, Zhang LK, Shen XR, Li SQ, Xu JR, Shang WJ, Gao ZB, Xia BQ. Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates. Acta Pharmacol Sin. 2021 Jul 22. PMID: 34294887.
      Citations: 2     Fields:    
    5. Su H, Yao S, Zhao W, Zhang Y, Liu J, Shao Q, Wang Q, Li M, Xie H, Shang W, Ke C, Feng L, Jiang X, Shen J, Xiao G, Jiang H, Zhang L, Ye Y, Xu Y. Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease. Nat Commun. 2021 06 15; 12(1):3623. PMID: 34131140.
      Citations: 7     Fields:    Translation:HumansCells
    6. Xia B, Shen X, He Y, Pan X, Liu FL, Wang Y, Yang F, Fang S, Wu Y, Duan Z, Zuo X, Xie Z, Jiang X, Xu L, Chi H, Li S, Meng Q, Zhou H, Zhou Y, Cheng X, Xin X, Jin L, Zhang HL, Yu DD, Li MH, Feng XL, Chen J, Jiang H, Xiao G, Zheng YT, Zhang LK, Shen J, Li J, Gao Z. SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target. Cell Res. 2021 08; 31(8):847-860. PMID: 34112954.
      Citations: 10     Fields:    Translation:HumansAnimals
    7. Wang Z, Zhao Y, Wang Q, Xing Y, Feng L, Kong J, Peng C, Zhang L, Yang H, Lu M. Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 Mpro. Signal Transduct Target Ther. 2021 06 01; 6(1):214. PMID: 34075025.
      Citations: 1     Translation:HumansAnimals
    8. Amporndanai K, Meng X, Shang W, Jin Z, Rogers M, Zhao Y, Rao Z, Liu ZJ, Yang H, Zhang L, O'Neill PM, Samar Hasnain S. Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives. Nat Commun. 2021 05 24; 12(1):3061. PMID: 34031399.
      Citations: 8     Fields:    Translation:Cells
    9. Wang Q, Luo Y, Shang W, Shi Z, Xiao G, Zhang L. Comprehensive interactome analysis of the spike protein of swine acute diarrhea syndrome coronavirus. Biosaf Health. 2021 Jun; 3(3):156-163. PMID: 34027383.
      Citations:    
    10. Zhang LK, Sun Y, Zeng H, Wang Q, Jiang X, Shang WJ, Wu Y, Li S, Zhang YL, Hao ZN, Chen H, Jin R, Liu W, Li H, Peng K, Xiao G. Author Correction: Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension. Cell Discov. 2021 May 03; 7(1):29. PMID: 33941764.
      Citations: 1     
    11. Ren PX, Shang WJ, Yin WC, Ge H, Wang L, Zhang XL, Li BQ, Li HL, Xu YC, Xu EH, Jiang HL, Zhu LL, Zhang LK, Bai F. A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors. Acta Pharmacol Sin. 2022 Feb; 43(2):483-493. PMID: 33907306.
      Citations: 2     Fields:    
    12. Dai W, Jochmans D, Xie H, Yang H, Li J, Su H, Chang D, Wang J, Peng J, Zhu L, Nian Y, Hilgenfeld R, Jiang H, Chen K, Zhang L, Xu Y, Neyts J, Liu H. Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2. J Med Chem. 2022 02 24; 65(4):2794-2808. PMID: 33872498.
      Citations: 2     Fields:    
    13. Zhao Y, Du X, Duan Y, Pan X, Sun Y, You T, Han L, Jin Z, Shang W, Yu J, Guo H, Liu Q, Wu Y, Peng C, Wang J, Zhu C, Yang X, Yang K, Lei Y, Guddat LW, Xu W, Xiao G, Sun L, Zhang L, Rao Z, Yang H. High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors. Protein Cell. 2021 11; 12(11):877-888. PMID: 33864621.
      Citations: 6     Fields:    Translation:HumansCells
    14. Yin W, Luan X, Li Z, Zhou Z, Wang Q, Gao M, Wang X, Zhou F, Shi J, You E, Liu M, Wang Q, Jiang Y, Jiang H, Xiao G, Zhang L, Yu X, Zhang S, Eric Xu H. Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin. Nat Struct Mol Biol. 2021 03; 28(3):319-325. PMID: 33674802.
      Citations: 12     Fields:    Translation:AnimalsCells
    15. Zeng HL, Lu QB, Yang Q, Wang X, Yue DY, Zhang LK, Li H, Liu W, Li HJ. Longitudinal Profile of Laboratory Parameters and Their Application in the Prediction for Fatal Outcome Among Patients Infected With SARS-CoV-2: A Retrospective Cohort Study. Clin Infect Dis. 2021 02 16; 72(4):626-633. PMID: 33048116.
      Citations: 2     Fields:    Translation:Humans
    16. Wu J, Shi Y, Pan X, Wu S, Hou R, Zhang Y, Zhong T, Tang H, Du W, Wang L, Wo J, Mu J, Qiu Y, Yang K, Zhang LK, Ye BC, Qi N. SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO. Cell Rep. 2021 02 16; 34(7):108761. PMID: 33567255.
      Citations: 31     Fields:    Translation:HumansCells
    17. Xiong R, Zhang L, Li S, Sun Y, Ding M, Wang Y, Zhao Y, Wu Y, Shang W, Jiang X, Shan J, Shen Z, Tong Y, Xu L, Chen Y, Liu Y, Zou G, Lavillete D, Zhao Z, Wang R, Zhu L, Xiao G, Lan K, Li H, Xu K. Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. Protein Cell. 2021 Jan; 12(1):76-80. PMID: 33029721.
      Citations:    Fields:    
    18. Zhang LK, Sun Y, Zeng H, Wang Q, Jiang X, Shang WJ, Wu Y, Li S, Zhang YL, Hao ZN, Chen H, Jin R, Liu W, Li H, Peng K, Xiao G. Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension. Cell Discov. 2020 Dec 22; 6(1):96. PMID: 33349633.
      Citations: 23     
    19. Wan W, Zhu S, Li S, Shang W, Zhang R, Li H, Liu W, Xiao G, Peng K, Zhang L. High-Throughput Screening of an FDA-Approved Drug Library Identifies Inhibitors against Arenaviruses and SARS-CoV-2. ACS Infect Dis. 2021 06 11; 7(6):1409-1422. PMID: 33183004.
      Citations: 8     Fields:    Translation:Humans
    20. Xiong R, Zhang L, Li S, Sun Y, Ding M, Wang Y, Zhao Y, Wu Y, Shang W, Jiang X, Shan J, Shen Z, Tong Y, Xu L, Chen Y, Liu Y, Zou G, Lavillette D, Zhao Z, Wang R, Zhu L, Xiao G, Lan K, Li H, Xu K. Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. Protein Cell. 2020 Nov 09. PMID: 33165830.
      Citations: 1     Fields:    
    21. Zhou Z, Zhou Y, Jiang XM, Wang Y, Chen X, Xiao G, Zhang CY, Yi Y, Zhang LK, Li L. Decreased HD-MIR2911 absorption in human subjects with the SIDT1 polymorphism fails to inhibit SARS-CoV-2 replication. Cell Discov. 2020; 6:63. PMID: 32934821.
      Citations: 4     
    22. Zhang L, Liu J, Cao R, Xu M, Wu Y, Shang W, Wang X, Zhang H, Jiang X, Sun Y, Hu H, Li Y, Zou G, Zhang M, Zhao L, Li W, Guo X, Zhuang X, Yang XL, Shi ZL, Deng F, Hu Z, Xiao G, Wang M, Zhong W. Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro. Virol Sin. 2020 Dec; 35(6):776-784. PMID: 32910347.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    23. Zhou LK, Zhou Z, Jiang XM, Zheng Y, Chen X, Fu Z, Xiao G, Zhang CY, Zhang LK, Yi Y. Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients. Cell Discov. 2020; 6(1):54. PMID: 32802404.
      Citations: 18     
    24. Xiong R, Zhang L, Li S, Sun Y, Ding M, Wang Y, Zhao Y, Wu Y, Shang W, Jiang X, Shan J, Shen Z, Tong Y, Xu L, Chen Y, Liu Y, Zou G, Lavillete D, Zhao Z, Wang R, Zhu L, Xiao G, Lan K, Li H, Xu K. Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. Protein Cell. 2020 10; 11(10):723-739. PMID: 32754890.
      Citations: 28     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    25. Su HX, Yao S, Zhao WF, Li MJ, Liu J, Shang WJ, Xie H, Ke CQ, Hu HC, Gao MN, Yu KQ, Liu H, Shen JS, Tang W, Zhang LK, Xiao GF, Ni L, Wang DW, Zuo JP, Jiang HL, Bai F, Wu Y, Ye Y, Xu YC. Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients. Acta Pharmacol Sin. 2020 Sep; 41(9):1167-1177. PMID: 32737471.
      Citations: 79     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    26. Lu QB, Jiang WL, Zhang X, Li HJ, Zhang XA, Zeng HL, Du J, Yang GL, Zhang LK, Li R, Fang LQ, Li H, Liu W. Comorbidities for fatal outcome among the COVID-19 patients: A hospital-based case-control study. J Infect. 2021 01; 82(1):159-198. PMID: 32731000.
      Citations: 5     Fields:    Translation:Humans
    27. Jin Z, Zhao Y, Sun Y, Zhang B, Wang H, Wu Y, Zhu Y, Zhu C, Hu T, Du X, Duan Y, Yu J, Yang X, Yang X, Yang K, Liu X, Guddat LW, Xiao G, Zhang L, Yang H, Rao Z. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nat Struct Mol Biol. 2020 06; 27(6):529-532. PMID: 32382072.
      Citations: 103     Fields:    Translation:AnimalsCellsPHPublic Health
    28. Dai W, Zhang B, Jiang XM, Su H, Li J, Zhao Y, Xie X, Jin Z, Peng J, Liu F, Li C, Li Y, Bai F, Wang H, Cheng X, Cen X, Hu S, Yang X, Wang J, Liu X, Xiao G, Jiang H, Rao Z, Zhang LK, Xu Y, Yang H, Liu H. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science. 2020 06 19; 368(6497):1331-1335. PMID: 32321856.
      Citations: 335     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    29. Mu J, Xu J, Zhang L, Shu T, Wu D, Huang M, Ren Y, Li X, Geng Q, Xu Y, Qiu Y, Zhou X. SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells. Sci China Life Sci. 2020 09; 63(9):1413-1416. PMID: 32291557.
      Citations: 34     Fields:    Translation:HumansCellsPHPublic Health
    30. Jin Z, Du X, Xu Y, Deng Y, Liu M, Zhao Y, Zhang B, Li X, Zhang L, Peng C, Duan Y, Yu J, Wang L, Yang K, Liu F, Jiang R, Yang X, You T, Liu X, Yang X, Bai F, Liu H, Liu X, Guddat LW, Xu W, Xiao G, Qin C, Shi Z, Jiang H, Rao Z, Yang H. Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 2020 06; 582(7811):289-293. PMID: 32272481.
      Citations: 758     Fields:    Translation:HumansCellsPHPublic Health
    31. Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, Shi Z, Hu Z, Zhong W, Xiao G. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 03; 30(3):269-271. PMID: 32020029.
      Citations: 2312     Fields:    Translation:HumansAnimalsCells
    32. Bernstein LR, Zhang L. Gallium maltolate has in vitro antiviral activity against SARS-CoV-2 and is a potential treatment for COVID-19. Antivir Chem Chemother. 2020 Jan-Dec; 28:2040206620983780. PMID: 33353394.
      Citations: 1     Fields:    Translation:AnimalsCells
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