Hualiang Jiang

InstitutionUniversity of Chinese Academy of Sciences
AddressBeijing
China
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 22 Covid-19 publications, with a maximum of 3 publications in April 2021
    All Publications
    Bar chart showing 702 publications over 20 distinct years, with a maximum of 64 publications in 2013
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

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    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Li H, Zhang D, Liang B, Zhong L, Cao Y, Shen J. Challenges for graduate students' mentors during COVID-19 pandemic. Biochem Mol Biol Educ. 2021 11; 49(6):841-842. PMID: 34390290.
      Citations:    Fields:    Translation:Humans
    2. Wang L, Wu Y, Yao S, Ge H, Zhu Y, Chen K, Chen WZ, Zhang Y, Zhu W, Wang HY, Guo Y, Ma PX, Ren PX, Zhang XL, Li HQ, Ali MA, Xu WQ, Jiang HL, Zhang LK, Zhu LL, Ye Y, Shang WJ, Bai F. Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein. Acta Pharmacol Sin. 2021 Aug 04. PMID: 34349236.
      Citations: 1     Fields:    
    3. Li S, Cai C, Gong J, Liu X, Li H. A fast protein binding site comparison algorithm for proteome-wide protein function prediction and drug repurposing. Proteins. 2021 11; 89(11):1541-1556. PMID: 34245187.
      Citations:    Fields:    Translation:Cells
    4. Su H, Yao S, Zhao W, Zhang Y, Liu J, Shao Q, Wang Q, Li M, Xie H, Shang W, Ke C, Feng L, Jiang X, Shen J, Xiao G, Jiang H, Zhang L, Ye Y, Xu Y. Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease. Nat Commun. 2021 06 15; 12(1):3623. PMID: 34131140.
      Citations: 7     Fields:    Translation:HumansCells
    5. Xia B, Shen X, He Y, Pan X, Liu FL, Wang Y, Yang F, Fang S, Wu Y, Duan Z, Zuo X, Xie Z, Jiang X, Xu L, Chi H, Li S, Meng Q, Zhou H, Zhou Y, Cheng X, Xin X, Jin L, Zhang HL, Yu DD, Li MH, Feng XL, Chen J, Jiang H, Xiao G, Zheng YT, Zhang LK, Shen J, Li J, Gao Z. SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target. Cell Res. 2021 08; 31(8):847-860. PMID: 34112954.
      Citations: 10     Fields:    Translation:HumansAnimals
    6. Ni L, Wen Z, Hu X, Tang W, Wang H, Zhou L, Wu L, Wang H, Xu C, Xu X, Xiao Z, Li Z, Li C, Liu Y, Duan J, Chen C, Li D, Zhang R, Li J, Yi Y, Huang W, Chen Y, Zhao J, Zuo J, Weng J, Jiang H, Wang DW. Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinical trial. Front Med. 2021 Oct; 15(5):704-717. PMID: 33909260.
      Citations: 2     Fields:    Translation:Humans
    7. Ren PX, Shang WJ, Yin WC, Ge H, Wang L, Zhang XL, Li BQ, Li HL, Xu YC, Xu EH, Jiang HL, Zhu LL, Zhang LK, Bai F. A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors. Acta Pharmacol Sin. 2022 Feb; 43(2):483-493. PMID: 33907306.
      Citations: 2     Fields:    
    8. Dai W, Jochmans D, Xie H, Yang H, Li J, Su H, Chang D, Wang J, Peng J, Zhu L, Nian Y, Hilgenfeld R, Jiang H, Chen K, Zhang L, Xu Y, Neyts J, Liu H. Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2. J Med Chem. 2022 02 24; 65(4):2794-2808. PMID: 33872498.
      Citations: 2     Fields:    
    9. Yin W, Luan X, Li Z, Zhou Z, Wang Q, Gao M, Wang X, Zhou F, Shi J, You E, Liu M, Wang Q, Jiang Y, Jiang H, Xiao G, Zhang L, Yu X, Zhang S, Eric Xu H. Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin. Nat Struct Mol Biol. 2021 03; 28(3):319-325. PMID: 33674802.
      Citations: 12     Fields:    Translation:AnimalsCells
    10. Long L, Wu L, Chen L, Zhou D, Wu H, Lu D, Li H, Duan X, Han Y, Li X, Wang Q, Zhang J. Effect of early oxygen therapy and antiviral treatment on disease progression in patients with COVID-19: A retrospective study of medical charts in China. PLoS Negl Trop Dis. 2021 01; 15(1):e0009051. PMID: 33406076.
      Citations: 2     Fields:    Translation:Humans
    11. Xiong R, Zhang L, Li S, Sun Y, Ding M, Wang Y, Zhao Y, Wu Y, Shang W, Jiang X, Shan J, Shen Z, Tong Y, Xu L, Chen Y, Liu Y, Zou G, Lavillete D, Zhao Z, Wang R, Zhu L, Xiao G, Lan K, Li H, Xu K. Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. Protein Cell. 2021 Jan; 12(1):76-80. PMID: 33029721.
      Citations:    Fields:    
    12. Xiong R, Zhang L, Li S, Sun Y, Ding M, Wang Y, Zhao Y, Wu Y, Shang W, Jiang X, Shan J, Shen Z, Tong Y, Xu L, Chen Y, Liu Y, Zou G, Lavillette D, Zhao Z, Wang R, Zhu L, Xiao G, Lan K, Li H, Xu K. Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. Protein Cell. 2020 Nov 09. PMID: 33165830.
      Citations: 1     Fields:    
    13. Xu Y, Jiang H. Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase. Protein Cell. 2020 10; 11(10):699-702. PMID: 32761523.
      Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    14. Xiong R, Zhang L, Li S, Sun Y, Ding M, Wang Y, Zhao Y, Wu Y, Shang W, Jiang X, Shan J, Shen Z, Tong Y, Xu L, Chen Y, Liu Y, Zou G, Lavillete D, Zhao Z, Wang R, Zhu L, Xiao G, Lan K, Li H, Xu K. Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. Protein Cell. 2020 10; 11(10):723-739. PMID: 32754890.
      Citations: 28     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    15. Yu B, Li C, Chen P, Li J, Jiang H, Wang DW. Beneficial effects exerted by hydroxychloroquine in treating COVID-19 patients via protecting multiple organs. Sci China Life Sci. 2021 02; 64(2):330-333. PMID: 32761451.
      Citations: 8     Fields:    Translation:Humans
    16. Su HX, Yao S, Zhao WF, Li MJ, Liu J, Shang WJ, Xie H, Ke CQ, Hu HC, Gao MN, Yu KQ, Liu H, Shen JS, Tang W, Zhang LK, Xiao GF, Ni L, Wang DW, Zuo JP, Jiang HL, Bai F, Wu Y, Ye Y, Xu YC. Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients. Acta Pharmacol Sin. 2020 Sep; 41(9):1167-1177. PMID: 32737471.
      Citations: 79     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    17. Hu K, Wang M, Zhao Y, Zhang Y, Wang T, Zheng Z, Li X, Zeng S, Zhao D, Li H, Xu K, Lan K. A Small-Scale Medication of Leflunomide as a Treatment of COVID-19 in an Open-Label Blank-Controlled Clinical Trial. Virol Sin. 2020 Dec; 35(6):725-733. PMID: 32696396.
      Citations: 8     Fields:    Translation:Humans
    18. Yu B, Li C, Chen P, Zhou N, Wang L, Li J, Jiang H, Wang DW. Erratum to: Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19. Sci China Life Sci. 2020 Oct; 63(10):1617-1618. PMID: 32572809.
      Citations: 3     Fields:    
    19. Yu B, Li C, Chen P, Zhou N, Wang L, Li J, Jiang H, Wang DW. Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19. Sci China Life Sci. 2020 10; 63(10):1515-1521. PMID: 32418114.
      Citations: 61     Fields:    Translation:HumansPHPublic Health
    20. Yin W, Mao C, Luan X, Shen DD, Shen Q, Su H, Wang X, Zhou F, Zhao W, Gao M, Chang S, Xie YC, Tian G, Jiang HW, Tao SC, Shen J, Jiang Y, Jiang H, Xu Y, Zhang S, Zhang Y, Xu HE. Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science. 2020 06 26; 368(6498):1499-1504. PMID: 32358203.
      Citations: 322     Fields:    Translation:Cells
    21. Dai W, Zhang B, Jiang XM, Su H, Li J, Zhao Y, Xie X, Jin Z, Peng J, Liu F, Li C, Li Y, Bai F, Wang H, Cheng X, Cen X, Hu S, Yang X, Wang J, Liu X, Xiao G, Jiang H, Rao Z, Zhang LK, Xu Y, Yang H, Liu H. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science. 2020 06 19; 368(6497):1331-1335. PMID: 32321856.
      Citations: 335     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    22. Jin Z, Du X, Xu Y, Deng Y, Liu M, Zhao Y, Zhang B, Li X, Zhang L, Peng C, Duan Y, Yu J, Wang L, Yang K, Liu F, Jiang R, Yang X, You T, Liu X, Yang X, Bai F, Liu H, Liu X, Guddat LW, Xu W, Xiao G, Qin C, Shi Z, Jiang H, Rao Z, Yang H. Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 2020 06; 582(7811):289-293. PMID: 32272481.
      Citations: 758     Fields:    Translation:HumansCellsPHPublic Health
    23. Hu T, Zhang Y, Li L, Wang K, Chen S, Chen J, Ding J, Jiang H, Shen X. Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure. Virology. 2009 Jun 05; 388(2):324-34. PMID: 19409595.
      Citations: 31     Fields:    Translation:Cells
    24. Chen S, Zhang J, Hu T, Chen K, Jiang H, Shen X. Residues on the dimer interface of SARS coronavirus 3C-like protease: dimer stability characterization and enzyme catalytic activity analysis. J Biochem. 2008 Apr; 143(4):525-36. PMID: 18182387.
      Citations: 14     Fields:    Translation:Cells
    25. Chen S, Hu T, Zhang J, Chen J, Chen K, Ding J, Jiang H, Shen X. Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: crystal structure with molecular dynamics simulations. J Biol Chem. 2008 Jan 04; 283(1):554-564. PMID: 17977841.
      Citations: 29     Fields:    Translation:Cells
    26. Chen L, Chen S, Gui C, Shen J, Shen X, Jiang H. Discovering severe acute respiratory syndrome coronavirus 3CL protease inhibitors: virtual screening, surface plasmon resonance, and fluorescence resonance energy transfer assays. J Biomol Screen. 2006 Dec; 11(8):915-21. PMID: 17092912.
      Citations: 14     Fields:    Translation:Cells
    27. Chen L, Li J, Luo C, Liu H, Xu W, Chen G, Liew OW, Zhu W, Puah CM, Shen X, Jiang H. Binding interaction of quercetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): structure-activity relationship studies reveal salient pharmacophore features. Bioorg Med Chem. 2006 Dec 15; 14(24):8295-306. PMID: 17046271.
      Citations: 74     Fields:    Translation:HumansCells
    28. Luo H, Chen J, Chen K, Shen X, Jiang H. Carboxyl terminus of severe acute respiratory syndrome coronavirus nucleocapsid protein: self-association analysis and nucleic acid binding characterization. Biochemistry. 2006 Oct 03; 45(39):11827-35. PMID: 17002283.
      Citations: 38     Fields:    Translation:Cells
    29. Hilgenfeld R, Anand K, Mesters JR, Rao Z, Shen X, Jiang H, Tan J, Verschueren KH. Structure and dynamics of SARS coronavirus main proteinase (Mpro). Adv Exp Med Biol. 2006; 581:585-91. PMID: 17037602.
      Citations: 6     Fields:    Translation:Cells
    30. Scandella E, Eriksson KK, Hertzig T, Drosten C, Chen L, Gui C, Luo X, Shen J, Shen X, Siddell SG, Ludewig B, Jiang H, Günther S, Thiel V. Identification and evaluation of coronavirus replicase inhibitors using a replicon cell line. Adv Exp Med Biol. 2006; 581:609-13. PMID: 17037607.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    31. Chen S, Luo H, Chen L, Chen J, Shen J, Zhu W, Chen K, Shen X, Jiang H. An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins: structures, functions and drug development. Curr Pharm Des. 2006; 12(35):4539-53. PMID: 17168760.
      Citations: 6     Fields:    Translation:Cells
    32. Chen S, Chen L, Chen K, Shen X, Jiang H. Techniques used for the discovery of therapeutic compounds: The case of SARS. Drug Discov Today Technol. 2006; 3(3):277-83. PMID: 24980529.
      Citations: 4     Fields:    
    33. Luo H, Wu D, Shen C, Chen K, Shen X, Jiang H. Severe acute respiratory syndrome coronavirus membrane protein interacts with nucleocapsid protein mostly through their carboxyl termini by electrostatic attraction. Int J Biochem Cell Biol. 2006; 38(4):589-99. PMID: 16343974.
      Citations: 23     Fields:    Translation:Cells
    34. Luo H, Ye F, Chen K, Shen X, Jiang H. SR-rich motif plays a pivotal role in recombinant SARS coronavirus nucleocapsid protein multimerization. Biochemistry. 2005 Nov 22; 44(46):15351-8. PMID: 16285739.
      Citations: 23     Fields:    Translation:Cells
    35. Tan J, Verschueren KH, Anand K, Shen J, Yang M, Xu Y, Rao Z, Bigalke J, Heisen B, Mesters JR, Chen K, Shen X, Jiang H, Hilgenfeld R. pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses. J Mol Biol. 2005 Nov 18; 354(1):25-40. PMID: 16242152.
      Citations: 71     Fields:    Translation:Cells
    36. Chen L, Gui C, Luo X, Yang Q, Günther S, Scandella E, Drosten C, Bai D, He X, Ludewig B, Chen J, Luo H, Yang Y, Yang Y, Zou J, Thiel V, Chen K, Shen J, Shen X, Jiang H. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J Virol. 2005 Jun; 79(11):7095-103. PMID: 15890949.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    37. Luo H, Chen Q, Chen J, Chen K, Shen X, Jiang H. The nucleocapsid protein of SARS coronavirus has a high binding affinity to the human cellular heterogeneous nuclear ribonucleoprotein A1. FEBS Lett. 2005 May 09; 579(12):2623-8. PMID: 15862300.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    38. Yu C, Gui C, Luo H, Chen L, Zhang L, Yu H, Yang S, Jiang W, Shen J, Shen X, Jiang H. Folding of the SARS coronavirus spike glycoprotein immunological fragment (SARS_S1b): thermodynamic and kinetic investigation correlating with three-dimensional structural modeling. Biochemistry. 2005 Feb 08; 44(5):1453-63. PMID: 15683230.
      Citations:    Fields:    Translation:Cells
    39. Chen S, Chen LL, Luo HB, Sun T, Chen J, Ye F, Cai JH, Shen JK, Shen X, Jiang HL. Enzymatic activity characterization of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer technique. Acta Pharmacol Sin. 2005 Jan; 26(1):99-106. PMID: 15659121.
      Citations: 14     Fields:    Translation:Cells
    40. Luo H, Ye F, Sun T, Yue L, Peng S, Chen J, Li G, Du Y, Xie Y, Yang Y, Shen J, Wang Y, Shen X, Jiang H. In vitro biochemical and thermodynamic characterization of nucleocapsid protein of SARS. Biophys Chem. 2004 Dec 01; 112(1):15-25. PMID: 15501572.
      Citations: 16     Fields:    Translation:Cells
    41. Chen S, Chen L, Tan J, Chen J, Du L, Sun T, Shen J, Chen K, Jiang H, Shen X. Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations. J Biol Chem. 2005 Jan 07; 280(1):164-73. PMID: 15507456.
      Citations: 45     Fields:    Translation:Cells
    42. Wu XD, Shang B, Yang RF, Yu H, Ma ZH, Shen X, Ji YY, Lin Y, Wu YD, Lin GM, Tian L, Gan XQ, Yang S, Jiang WH, Dai EH, Wang XY, Jiang HL, Xie YH, Zhu XL, Pei G, Li L, Wu JR, Sun B. The spike protein of severe acute respiratory syndrome (SARS) is cleaved in virus infected Vero-E6 cells. Cell Res. 2004 Oct; 14(5):400-6. PMID: 15450134.
      Citations: 28     Fields:    Translation:AnimalsCells
    43. Luo C, Luo H, Zheng S, Gui C, Yue L, Yu C, Sun T, He P, Chen J, Shen J, Luo X, Li Y, Liu H, Bai D, Shen J, Yang Y, Li F, Zuo J, Hilgenfeld R, Pei G, Chen K, Shen X, Jiang H. Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A. Biochem Biophys Res Commun. 2004 Aug 27; 321(3):557-65. PMID: 15358143.
      Citations: 53     Fields:    Translation:HumansCells
    44. Sun H, Luo H, Yu C, Sun T, Chen J, Peng S, Qin J, Shen J, Yang Y, Xie Y, Chen K, Wang Y, Shen X, Jiang H. Molecular cloning, expression, purification, and mass spectrometric characterization of 3C-like protease of SARS coronavirus. Protein Expr Purif. 2003 Dec; 32(2):302-8. PMID: 14965777.
      Citations: 13     Fields:    Translation:Cells
    45. Yu XJ, Luo C, Lin JC, Hao P, He YY, Guo ZM, Qin L, Su J, Liu BS, Huang Y, Nan P, Li CS, Xiong B, Luo XM, Zhao GP, Pei G, Chen KX, Shen X, Shen JH, Zou JP, He WZ, Shi TL, Zhong Y, Jiang HL, Li YX. Putative hAPN receptor binding sites in SARS_CoV spike protein. Acta Pharmacol Sin. 2003 Jun; 24(6):481-8. PMID: 12791172.
      Citations: 10     Fields:    Translation:HumansCells
    46. Qin L, Xiong B, Luo C, Guo ZM, Hao P, Su J, Nan P, Feng Y, Shi YX, Yu XJ, Luo XM, Chen KX, Shen X, Shen JH, Zou JP, Zhao GP, Shi TL, He WZ, Zhong Y, Jiang HL, Li YX. Identification of probable genomic packaging signal sequence from SARS-CoV genome by bioinformatics analysis. Acta Pharmacol Sin. 2003 Jun; 24(6):489-96. PMID: 12791173.
      Citations: 11     Fields:    Translation:HumansCells
    47. Xiong B, Gui CS, Xu XY, Luo C, Chen J, Luo HB, Chen LL, Li GW, Sun T, Yu CY, Yue LD, Duan WH, Shen JK, Qin L, Shi TL, Li YX, Chen KX, Luo XM, Shen X, Shen JH, Jiang HL. A 3D model of SARS_CoV 3CL proteinase and its inhibitors design by virtual screening. Acta Pharmacol Sin. 2003 Jun; 24(6):497-504. PMID: 12791174.
      Citations: 29     Fields:    Translation:HumansCells
    48. Shen X, Xue JH, Yu CY, Luo HB, Qin L, Yu XJ, Chen J, Chen LL, Xiong B, Yue LD, Cai JH, Shen JH, Luo XM, Chen KX, Shi TL, Li YX, Hu GX, Jiang HL. Small envelope protein E of SARS: cloning, expression, purification, CD determination, and bioinformatics analysis. Acta Pharmacol Sin. 2003 Jun; 24(6):505-11. PMID: 12791175.
      Citations: 18     Fields:    Translation:HumansCells
    49. Lin Y, Shen X, Yang RF, Li YX, Ji YY, He YY, Shi MD, Lu W, Shi TL, Wang J, Wang HX, Jiang HL, Shen JH, Xie YH, Wang Y, Pei G, Shen BF, Wu JR, Sun B. Identification of an epitope of SARS-coronavirus nucleocapsid protein. Cell Res. 2003 Jun; 13(3):141-5. PMID: 12862314.
      Citations: 32     Fields:    Translation:HumansAnimalsCellsPHPublic Health
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