F-Box-WD Repeat-Containing Protein 7
"F-Box-WD Repeat-Containing Protein 7" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.
| Descriptor ID |
D000073979
|
| MeSH Number(s) |
D08.811.464.938.750.750.750 D12.776.157.169.750 D12.776.167.242
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| Concept/Terms |
F-Box-WD Repeat-Containing Protein 7- F-Box-WD Repeat-Containing Protein 7
- F Box WD Repeat Containing Protein 7
- F-Box and WD-40 Domain-Containing Protein 7
- F Box and WD 40 Domain Containing Protein 7
- FBXW7 Protein
|
Below are MeSH descriptors whose meaning is more general than "F-Box-WD Repeat-Containing Protein 7".
Below are MeSH descriptors whose meaning is more specific than "F-Box-WD Repeat-Containing Protein 7".
This graph shows the total number of publications written about "F-Box-WD Repeat-Containing Protein 7" by people in this website by year, and whether "F-Box-WD Repeat-Containing Protein 7" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "F-Box-WD Repeat-Containing Protein 7" by people in Profiles.
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PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis. Cell Commun Signal. 2019 03 29; 17(1):30.
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Regulation of HSF1 protein stabilization: An updated review. Eur J Pharmacol. 2018 Mar 05; 822:69-77.
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Cell cycle-dependent degradation of the methyltransferase SETD3 attenuates cell proliferation and liver tumorigenesis. J Biol Chem. 2017 06 02; 292(22):9022-9033.
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Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation. J Exp Clin Cancer Res. 2017 01 10; 36(1):10.
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Ubiquitin ligase Fbw7 restricts the replication of hepatitis C virus by targeting NS5B for ubiquitination and degradation. Biochem Biophys Res Commun. 2016 Feb 12; 470(3):697-703.