"DEAD Box Protein 58" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).
| Descriptor ID |
D000071457
|
| MeSH Number(s) |
D08.811.913.696.445.735.720.249.750
|
| Concept/Terms |
DEAD Box Protein 58- DEAD Box Protein 58
- DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58
- Probable ATP-Dependent RNA Helicase DDX58
- Probable ATP Dependent RNA Helicase DDX58
- RIG-I-like Receptor 1
- RIG I like Receptor 1
|
Below are MeSH descriptors whose meaning is more general than "DEAD Box Protein 58".
Below are MeSH descriptors whose meaning is more specific than "DEAD Box Protein 58".
This graph shows the total number of publications written about "DEAD Box Protein 58" by people in this website by year, and whether "DEAD Box Protein 58" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 0 | 2 | 2 |
| 2017 | 14 | 9 | 23 |
| 2018 | 7 | 3 | 10 |
| 2019 | 3 | 1 | 4 |
| 2020 | 2 | 2 | 4 |
| 2021 | 3 | 4 | 7 |
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Below are the most recent publications written about "DEAD Box Protein 58" by people in Profiles.
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All-Trans Retinoic Acid Exhibits Antiviral Effect against SARS-CoV-2 by Inhibiting 3CLpro Activity. Viruses. 2021 08 23; 13(8).
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A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder. Cell Signal. 2021 11; 87:110121.
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SARS-CoV-2 N Protein Targets TRIM25-Mediated RIG-I Activation to Suppress Innate Immunity. Viruses. 2021 07 23; 13(8).
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Structural insights into the distinctive RNA recognition and therapeutic potentials of RIG-I-like receptors. Med Res Rev. 2022 01; 42(1):399-425.
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SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation. EMBO J. 2021 08 02; 40(15):e107826.
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A Comparative Analysis of Coronavirus Nucleocapsid (N) Proteins Reveals the SADS-CoV N Protein Antagonizes IFN-ß Production by Inducing Ubiquitination of RIG-I. Front Immunol. 2021; 12:688758.
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Opposing forces fight over the same ground to regulate interferon signaling. Biochem J. 2021 05 28; 478(10):1853-1859.
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SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1. Front Immunol. 2021; 12:662989.
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RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells. Nat Immunol. 2021 07; 22(7):820-828.
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SARS-CoV-2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING signaling pathways. J Med Virol. 2021 09; 93(9):5376-5389.