Proto-Oncogene Proteins c-kit
"Proto-Oncogene Proteins c-kit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
| Descriptor ID |
D019009
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.050 D12.776.543.750.630.124 D12.776.543.750.705.852.150.100 D12.776.543.750.750.400.200.170 D12.776.624.664.700.183
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| Concept/Terms |
Proto-Oncogene Proteins c-kit- Proto-Oncogene Proteins c-kit
- Proto Oncogene Proteins c kit
- c-kit, Proto-Oncogene Proteins
- Stem Cell Factor Receptor
- SCF Receptor
- p145 c-kit
- c-kit, p145
- p145 c kit
- p145(c-kit)
- p145c-kit
- p145c kit
- CD117 Antigen
- Antigens, CD117
- CD117 Antigens
- Proto-Oncogene Protein c-kit
- Proto Oncogene Protein c kit
- c-kit, Proto-Oncogene Protein
- c-kit Protein
- c kit Protein
- kit Proto-Oncogene Protein
- Proto-Oncogene Protein, kit
- kit Proto Oncogene Protein
- Receptor, Stem Cell Factor
- Proto-Oncogene Protein kit
- Proto Oncogene Protein kit
- c-kit Receptor
- c kit Receptor
|
Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-kit".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-kit".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-kit" by people in this website by year, and whether "Proto-Oncogene Proteins c-kit" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2010 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 2 | 1 | 3 |
| 2016 | 0 | 2 | 2 |
| 2017 | 5 | 9 | 14 |
| 2018 | 6 | 10 | 16 |
| 2019 | 2 | 1 | 3 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-kit" by people in Profiles.
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Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells. Bull Exp Biol Med. 2020 Nov; 170(1):118-122.
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Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis. Front Immunol. 2020; 11:574862.
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Detection of KIT D816V mutation in patients with severe anaphylaxis and normal basal tryptase-first data from the Anaphylaxis Registry (NORA). J Allergy Clin Immunol. 2019 11; 144(5):1448-1450.e1.
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Discovery of ( E)- N1-(3-Fluorophenyl)- N3-(3-(2-(pyridin-2-yl)vinyl)-1 H-indazol-6-yl)malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs). J Med Chem. 2019 05 23; 62(10):5006-5024.
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Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome. J Allergy Clin Immunol Pract. 2019 04; 7(4):1125-1133.e1.
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Innate lymphoid cells in the upper airways: importance of CD117 and IL-1RI expression. Eur Respir J. 2018 12; 52(6).
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TET2 deficiency leads to stem cell factor-dependent clonal expansion of dysfunctional erythroid progenitors. Blood. 2018 11 29; 132(22):2406-2417.
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EPIGIST: An observational real-life study on patients with metastatic gastrointestinal stromal tumors receiving imatinib. PLoS One. 2018; 13(9):e0204117.
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The Italian Mastocytosis Registry: 6-year experience from a hospital-based registry. Future Oncol. 2018 11; 14(26):2713-2723.
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Identification of Myocardial Telocytes and Bone Marrow Mesenchymal Stem Cells in Mice. Cell Transplant. 2018 10; 27(10):1515-1522.