Low Density Lipoprotein Receptor-Related Protein-6
"Low Density Lipoprotein Receptor-Related Protein-6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An LDL-receptor related protein that combines with cell surface FRIZZLED RECEPTORS to form WNT PROTEIN-binding receptors. The protein plays an important role in the WNT SIGNALING PATHWAY during EMBRYONIC DEVELOPMENT and in regulation of vascular cell proliferation.
| Descriptor ID |
D060488
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| MeSH Number(s) |
D12.776.526.600 D12.776.543.750.710.450.500.600 D12.776.543.750.850.781
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| Concept/Terms |
Low Density Lipoprotein Receptor-Related Protein-6- Low Density Lipoprotein Receptor-Related Protein-6
- Low Density Lipoprotein Receptor Related Protein 6
- Low Density Lipoprotein Receptor-Related Protein 6
- Lipoprotein Receptor-Related Protein 6
- Lipoprotein Receptor Related Protein 6
|
Below are MeSH descriptors whose meaning is more general than "Low Density Lipoprotein Receptor-Related Protein-6".
Below are MeSH descriptors whose meaning is more specific than "Low Density Lipoprotein Receptor-Related Protein-6".
This graph shows the total number of publications written about "Low Density Lipoprotein Receptor-Related Protein-6" by people in this website by year, and whether "Low Density Lipoprotein Receptor-Related Protein-6" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2018 | 3 | 4 | 7 |
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Below are the most recent publications written about "Low Density Lipoprotein Receptor-Related Protein-6" by people in Profiles.
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Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9135-E9144.
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Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6. FEBS Lett. 2018 09; 592(18):3152-3162.
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Tumor promoter TPA activates Wnt/ß-catenin signaling in a casein kinase 1-dependent manner. Proc Natl Acad Sci U S A. 2018 08 07; 115(32):E7522-E7531.
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Capillary morphogenesis gene 2 maintains gastric cancer stem-like cell phenotype by activating a Wnt/ß-catenin pathway. Oncogene. 2018 07; 37(29):3953-3966.
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CircLRP6 Regulation of ZEB1 via miR-455 Is Involved in the Epithelial-Mesenchymal Transition During Arsenite-Induced Malignant Transformation of Human Keratinocytes. Toxicol Sci. 2018 04 01; 162(2):450-461.
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Gigantol inhibits Wnt/ß-catenin signaling and exhibits anticancer activity in breast cancer cells. BMC Complement Altern Med. 2018 Feb 14; 18(1):59.
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Cardiomyocyte-Restricted Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) Deletion Leads to Lethal Dilated Cardiomyopathy Partly Through Drp1 Signaling. Theranostics. 2018; 8(3):627-643.
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Functional analysis LRP6 novel mutations in patients with coronary artery disease. PLoS One. 2014; 9(1):e84345.